Benjamin J. Sprague

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Hemodynamic shear stress is the most powerful physiological regulator of endothelial Nitric Oxide Synthase (eNOS), leading to rapid rises in nitric oxide (NO). The substantial increases in uterine and placental blood flows throughout gestation rely heavily on the action of NO. We and others have investigated endothelial function in response to shear stress(More)
OBJECTIVES Changes in uterine vascular impedance may yield diagnostic insight into physiological and pathological changes in uterine vascular resistance and compliance during the ovarian cycle and pregnancy. Herein, our objectives were to develop models to simulate uterine vascular impedance in order to gain insight into the vascular size and stiffness(More)
Popular models for describing the luminosity-density profiles of dynamically hot stellar systems (e.g., Jaffe, Hernquist, Dehnen) were constructed to match the deprojected form of de Vaucouleurs’ R light-profile. However, we now know that elliptical galaxies and bulges display a mass-dependent range of structural profiles. To compensate this, the model in(More)
OBJECTIVES Uterine vascular resistance (UVR) is the ratio of systemic mean arterial pressure to mean uterine blood flow and is sensitive to changes in small arteries and arterioles. However, it provides little or no insight into changes in large, conduit arteries. Fluctuations in estrogen (E2) and progesterone (P4) levels during the ovarian cycle are(More)
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