Benjamin Hewins

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BACKGROUND Microvascular dysfunction in HCM has been associated with adverse clinical outcomes. Advances in quantitative cardiovascular magnetic resonance (CMR) perfusion imaging now allow myocardial blood flow to be quantified at the pixel level. We applied these techniques to investigate the spectrum of microvascular dysfunction in hypertrophic(More)
The effects of dietary carbohydrate (CHO) content and of tri-iodothyronine (T3) administration on calcium, zinc and phosphate balances and on urinary hydroxyproline output were examined in eight obese subjects undergoing therapy with low energy (2741-3301 kJ/day), high calcium (28.9-35.1 mmol/day) diets. Calcium balances were generally positive at the high(More)
A 95-year-old woman presented in cardiac arrest. She had been intubated and positive pressure ventilation had been administered by paramedics. Air was aspirated during cannulation of the subclavian vein and the femoral artery. Chest roentgenogram revealed the heart and great vessels filled with air. Massive air embolism caused by positive pressure(More)
Background Abuse of anabolic steroids to induce skeletal muscle hypertrophy is widespread amongst recreational bodybuilders, however, the cardiac effects of such drugs have not been systematically documented. The ability of cardiovascular magnetic resonance (CMR) to image the myocardium in any plane and achieve full myocardial coverage renders it the gold(More)
Background Interstitial fibrosis is a pathological hallmark of hypertrophic cardiomyopathy (HCM) and is thought to contribute to the abnormal myocardial mechanics seen in this patient group. T1-mapping now allows interstitial fibrosis to be detected non-invasively. Replacement fibrosis as identified by late gadolinium enhancement imaging has been associated(More)
Non-invasive assessment of interstitial myocardial fibrosis in pressure-overload left ventricular hypertrophy Andrew Jabbour, Tevfik F Ismail, Sofia V De Noronha, Carl Shakespeare, Sameer Zaman, Oluwatosin Sotubo, Saman S Zaman, Callum Ettles, Benjamin Hewins, Rick Wage, Ankur Gulati, Pedro F Ferreira, Pierre Croisille, Yanqiu Feng, Katsuya Norita, Raad H(More)
Methods Twenty one body-builders were studied 14 anabolic steroid users and 7 controls matched for age and training history. First pass CMR perfusion imaging was performed on a 1.5T Avanto (Siemens, Erlangen, Germany) after adenosine-induced hyperemia (140 mcg/kg/min) and at rest using a hybrid echo-planar imaging sequence. Images of the base, mid-ventricle(More)
Background Hypertrophic cardiomyopathy (HCM) is associated with increased myocardial fibrosis and collagen deposition. Collagen reduces cardiovascular magnetic resonance (CMR) derived T2 times, however, the inflammatory milieu required for its deposition is often associated with localised oedema. Focal areas of high T2 signal intensity have been reported in(More)
Potential of pre-contrast T1 mapping as a marker of interstitial fibrosis in severe aortic stenosis Andrew Jabbour, Tevfik F Ismail, Callum Ettles, Carl Shakespeare, Sameer Zaman, Oluwatosin Sotubo, Saman S Zaman, Benjamin Hewins, Rick Wage, Ankur Gulati, Pedro F Ferreira, Pierre Croisille, Yanqiu Feng, Raad H Mohiaddin, Taigang He, John Pepper, David N(More)
Background Fibrosis is thought to play an important role in the pathogenesis of the adverse sequelae of hypertrophic cardiomyopathy (HCM). Late gadolinium enhancement (LGE) cardiovascular magnetic resonance detects replacement fibrosis but cannot presently detect interstitial fibrosis. The latter is thought to be a very early feature of HCM and can be(More)