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Copper, zinc, selenium, and molybdenum are involved in many biochemical processes supporting life. The most important of these processes are cellular respiration, cellular utilization of oxygen, DNA and RNA reproduction, maintenance of cell membrane integrity, and sequestration of free radicals. Copper, zinc, and selenium are involved in destruction of free(More)
The maximum stability conditions for cocaine and its metabolite benzoylecgonine (BE) in urine were analyzed. Suggestions were presented after careful review of many studies and personal communications concerning cocaine and BE stability in urine. The optimal storage conditions for urine specimens with cocaine and BE were determined to be at -15 degrees C(More)
There are many disease states in the elderly that mandate the use of drugs with extremely narrow therapeutic indexes and potentially fatal toxicity. Digoxin is one example of such drugs. It is extensively used for the treatment of congestive heart failure of diverse origin and of cardiac arrhythmias of supraventricular origin. Aging can produce changes in(More)
The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels. These levels may be determined by equilibrium(More)
While the correlation between plasma levels of some tricyclic antidepressants and therapeutic efficacy is well documented and the value of tricyclic antidepressant plasma level measurements is reasonably well established, the sources of error in the collection and analysis of specimens are not generally known and understood. An outline of the factors(More)
In summary, we review the recent and not so recent but lesser known information on lead poisoning. We review the incidence of lead poisoning and find that no one is really safe from its effects. We have also examined the many and varied sources of lead poisoning, and critically review the ubiquitous ways in which lead enters the body and is eventually dealt(More)
There currently are three clinical laboratory procedures for use with cerebrospinal fluid that assist in the diagnosis of multiple sclerosis: measurement of myelin basic protein and IgG, and demonstration of an oligoclonal band. We compared characteristics of these procedures, using CSF samples from 166 patients identified as having (54 patients) or not(More)
The in vitro activity of A21978C1, a novel cyclic polypeptide antibiotic, was compared with those of vancomycin, teichomycin, and several beta-lactam antibiotics against gram-positive bacteria. The new drug was at least as active as vancomycin against all species of streptococci and staphylococci tested, including methicillin-resistant Staphylococcus aureus(More)