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The advent of high-throughput short read technology is revolutionizing life sciences by providing an inexpensive way to sequence genomes at high coverage. Exploiting this technology requires the development of a de novo short read assembler, which is an important open problem that is garnering significant research effort. Current methods are largely limited(More)
A genetic map is an ordering of genetic markers constructed from genetic linkage data for use in linkage studies and experimental design. While traditional methods have focused on constructing maps from a single population study, increasingly maps are generated for multiple lines and populations of the same organism. For example, in crop plants, where the(More)
Graph theoretic models for genome assembly are continually being proposed and refined. At the same time, large scale assembly projects rely on the overlap-layout-consensus assembly paradigm, in which the best pairwise alignments serve as seeds for a greedy extension of contigs. These methods, which largely rely on local information, are used despite(More)
OBJECTIVE Ventilator-dependent preterm infants are often treated with a prolonged tapering course of dexamethasone to decrease the risk and severity of chronic lung disease. The objective of this study was to assess the effect of this therapy on developmental outcome at 1 year of age. METHODS Study participants were 118 very low birth weight infants who,(More)
Aim Recent meta-analyses have revealed that plant traits and their phylogenetic history influence decay rates of dead wood and leaf litter, but it remains unknown if decay rates of wood and litter covary over a wide range of tree species and across ecosystems. We evaluated the relationships between species-specific wood and leaf litter decomposability, as(More)
A genetic map is an ordering of geneticmarkers calculated from a population of known lineage.While traditionally a map has been generated from a singlepopulation for each species, recently researchers have createdmaps from multiple populations. In the face of thesenew data, we address the need to find a consensus map — a map that combines the(More)
BACKGROUND The de novo assembly of genomes and transcriptomes from short sequences is a challenging problem. Because of the high coverage needed to assemble short sequences as well as the overhead of modeling the assembly problem as a graph problem, the methods for short sequence assembly are often validated using data from BACs or small sized prokaryotic(More)
Recent studies have shown that accounting for intraspecific trait variation (ITV) may better address major questions in community ecology. However, a general picture of the relative extent of ITV compared to interspecific trait variation in plant communities is still missing. Here, we conducted a meta-analysis of the relative extent of ITV within and among(More)
Feather mosses form a thick ground layer in boreal forests that can intercept incoming litter fall. This interception may influence the decomposition of incoming litter but this has been little explored. We investigated how the moss layer influences decomposition of intercepted litter along a 362-year fire driven forest chronosequence in northern Sweden(More)