Benjamin F. Lane

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One of the biggest challenges associated with a nulling-interferometer-based approach to detecting extrasolar Earthlike planets comes from the extremely stringent requirements of path length, polarization, and amplitudematching in the interferometer. To the extent that the light from multiple apertures is not matched in these properties, light will leak(More)
The base lesion 8-oxoguanine is formed readily by oxidation of DNA, potentially leading to G → T transversion mutations. Despite the apparent similarity of 8-oxoguanine-cytosine base pairs to normal guanine-cytosine base pairs, cellular base excision repair systems effectively recognize the lesion base. Here we apply several techniques to examine a single(More)
The Palomar Testbed Interferometer (PTI) is a long-baseline infrared interferometer located at Palomar Observatory, California. It was built as a testbed for interferometric techniques applicable to the Keck Interferometer. First fringes were obtained in July 1995. PTI implements a dual-star architecture, tracking two stars simultaneously for phase(More)
Interruption of TGFbeta signaling through inhibition of the TGFbetaR1 kinase domain may prove to have beneficial effect in both fibrotic and oncological diseases. Herein we describe the SAR of a novel series of TGFbetaR1 kinase inhibitors containing a pyrazolone core. Most TGFbetaR1 kinase inhibitors described to date contain a core five-membered ring(More)
We have made simultaneous and nearly simultaneous measurements of L0, the outer scale of turbulence, at the Palomar Observatory by using three techniques: angle-of-arrival covariance measurements with the Generalized Seeing Monitor (GSM), differential-image-motion measurements with the adaptive-optics system on the Hale 5-m telescope, and fringe speed(More)
The cis-syn thymine cyclobutane dimer is a DNA photoproduct implicated in skin cancer. We compared the stability of individual base pairs in thymine dimer-containing duplexes to undamaged parent 10-mer duplexes. UV melting thermodynamic measurements, CD spectroscopy, and 2D NOESY NMR spectroscopy confirm that the thymine dimer lesion is locally and(More)
We present flight results from the optical pointing control system onboard the Planetary Imaging Concept Testbed Using a Rocket Experiment (PICTURE) sounding rocket. PICTURE (NASA mission number: 36.225 UG) was launched on 8 October 2011, from White Sands Missile Range. It attempted to directly image the exozodiacal dust disk of ϵ Eridani (K2V, 3.22 pc)(More)
OBJECTIVE The aim of this study was to quantify the correlation between adenosine triphosphate (ATP) measurements and bacterial cultures from duodenoscopes for evaluation of contamination following high-level disinfection. DESIGN Duodenoscopes used for any intended endoscopic retrograde cholangiopancreatography (ERCP) procedure were included. Microbiologic(More)
V819 Herculis is a well-studied triple star system consisting of a “wide” pair with 5.5 year period, one component of which is a 2.2-day period eclipsing single-line spectroscopic binary. Differential astrometry measurements from the Palomar High-precision Astrometric Search for Exoplanet Systems (PHASES) are presented and used to determine a relative(More)
κ Pegasi is a well-known, nearby triple star system. It consists of a “wide” pair with semi-major axis 235 milli-arcseconds, one component of which is a single-line spectroscopic binary (semi-major axis 2.5 milli-arcseconds). Using high-precision differential astrometry and radial velocity observations, the masses for all three components are determined and(More)