Mary A Raven20
Patrick W Keeley14
Irene E Whitney9
20Mary A Raven
14Patrick W Keeley
9Irene E Whitney
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  • Seong-Seng Tan, Michael Kalloniatis, Karin Sturm, Patrick P.L Tam, Benjamin E Reese, Beverly Faulkner-Jones
  • 1998
Cell lineage analyses suggest that cortical neuroblasts are capable of undertaking both radial and tangential modes of cell movement. However, it is unclear whether distinct progenitors are committed to generating neuroblasts that disperse exclusively in either radial or tangential directions. Using highly unbalanced mouse stem cell chimeras, we have(More)
  • Robert Cantrup, Rajiv Dixit, Elena Palmesino, Stephan Bonfield, Tarek Shaker, Nobuhiko Tachibana +9 others
  • 2012
BACKGROUND The retina has a unique three-dimensional architecture, the precise organization of which allows for complete sampling of the visual field. Along the radial or apicobasal axis, retinal neurons and their dendritic and axonal arbors are segregated into layers, while perpendicular to this axis, in the tangential plane, four of the six neuronal types(More)
The dendritic patterning of retinal horizontal cells has been shown to be specified by the cone photoreceptor afferents. The present investigation has addressed whether this specification is due to visually dependent synaptic transmission in the outer plexiform layer or to some other early, pre-visual, neural activity. Individually labeled horizontal cells(More)
  • Patrick W Keeley, Irene E Whitney, Nils R Madsen, Ace J St John, Sarra Borhanian, Stephanie A Leong +2 others
  • 2014
The sizes of different neuronal populations within the CNS are precisely controlled, but whether neuronal number is coordinated between cell types is unknown. We examined the covariance structure of 12 different retinal cell types across 30 genetically distinct lines of mice, finding minimal covariation when comparing synaptically connected or(More)
During development of the retina, programmed cell death helps to establish the final size and distribution of various cell classes in distinct layers of the tissue. Here we show that dying cells in the developing ganglion and inner nuclear layers are clustered spatially and that gap junction inhibitors decrease the clustering of dying cells. To confirm the(More)
Individual types of retinal nerve cell are spaced across the retina in an orderly manner, ensuring a uniform sampling of the visual field. This regularity in cellular spacing has been commonly attributed to fate determination mechanisms operating around the time of cell birth, an hypothesis presuming that the position of a nerve cell is fixed within the(More)
Although much is known about the transcriptional regulation that coordinates retinal cell fate determination, very little is known about the developmental processes that establish the characteristic laminar architecture of the retina, in particular, the specification of neuronal positioning. The LIM class homeodomain transcription factor Lim1 (Lhx1) is(More)
Among eutherian mammals, only primates possess trichromatic color vision. In Old World primates, trichromacy was made possible by a visual pigment gene duplication. In most New World primates, trichromacy is based on polymorphic variation in a single X-linked gene that produces, by random X inactivation, a patchy mosaic of spectrally distinct cone(More)
The two populations of cholinergic amacrine cells in the inner nuclear layer (INL) and the ganglion cell layer (GCL) differ in their spatial organization in the mouse retina, but the basis for this difference is not understood. The present investigation examined this issue in six strains of mice that differ in their number of cholinergic cells, addressing(More)