Benjamin Dean

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OBJECTIVE To investigate whether placebo controls should be used in the evaluation of surgical interventions. DESIGN Systematic review. DATA SOURCES We searched Medline, Embase, and the Cochrane Controlled Trials Register from their inception to November 2013. STUDY SELECTION Randomised clinical trials comparing any surgical intervention with placebo.(More)
BACKGROUND Arthroscopic subacromial decompression (ASAD) is a commonly performed surgical intervention for shoulder pain. The rationale is that removal of a bony acromial spur relieves symptoms by decompressing rotator cuff tendons passing through the subacromial space. However, the efficacy of this procedure is uncertain. The objective of this trial was to(More)
The regulatory mechanisms involved in tendon homeostasis and repair are not fully understood. Accumulating data, however, demonstrate that the nervous system, in addition to afferent (sensory) functions, through efferent pathways plays an active role in regulating pain, inflammation, and tissue repair. In normal-, healing- and tendinopathic tendons three(More)
BACKGROUND Understanding changes in the placebo arm is essential for correct design and interpretation of randomized controlled trials (RCTs). It is assumed that placebo response, defined as the total improvement in the placebo arm of surgical trials, is large; however, its precise magnitude and properties remain to be characterized. To the best of our(More)
Introduction: Shoulder pain is the third most frequent cause of chronic musculoskeletal pain in the community predominantly caused by rotator cuff tendinopathy RCT). The glutaminergic system is of key importance in driving the peripheral and central neuronal changes which increase the body's sensitivity to pain (1, 2, 3). Glutamate induced excitotoxicity(More)
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