Benjamin D . Gold

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The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence that ideR is an essential gene in Mycobacterium(More)
In this work, we characterize genes in Mycobacterium tuberculosis that are regulated by IdeR (iron-dependent regulator), an iron-responsive DNA-binding protein of the DtxR family that has been shown to regulate iron acquisition in Mycobacterium smegmatis. To identify some of the genes that constitute the IdeR regulon, we searched the M. tuberculosis genome(More)
OBJECTIVE As the clinical implications of Helicobacter pylori infection in children and adolescents continue to evolve, ESPGHAN and NASPGHAN jointly renewed clinical guidelines using a standardized evidence-based approach to develop updated recommendations for children and adolescents in North America and Europe. METHODS An international panel of 11(More)
OBJECTIVES:To develop an international consensus on the definition of gastroesophageal reflux disease (GERD) in the pediatric population.METHODS:Using the Delphi process, a set of statements was developed and voted on by an international panel of eight pediatric gastroenterologists. Statements were based on systematic literature searches using Medline,(More)
Helicobacter pylori(H. pylori)는 만성 위염과 소화성 궤양 등의 원인균으로 잘 알려져 있으며 위암과 mucosa associated lymphoid tissue(MALT)와의 관련성도 체계적으로 밝혀져 있 다. 개발도상국에서 H. pylori는 어려서부터 감염되게 되는데 대 부분의 경우 10세 이전에 감염이 시작된다 1) . 한번 감염되면 수 십 년 지속되는 것이 보통이며 자연 박멸률은 극히 낮다 2) . 한국 인에서의 H. pylori 감염의 혈청학적 역학 연구결과에서 보면, 5 세 미만에 1.1%, 5-10세 사이에 12.8%, 10-15세 사이에 20.4% 인 양성률이 20대에 들어서면 66.7%로 급격히(More)
Across populations of children, Helicobacter pylori prevalence ranges from under 10% to over 80%. Low prevalence occurs in the U.S., Canada, and northern and western Europe; high prevalence occurs in India, Africa, Latin America, and eastern Europe. Risk factors include socioeconomic status, household crowding, ethnicity, migration from high prevalence(More)
OBJECTIVES:Antireflux surgery is performed frequently in children with gastroesophageal reflux disease (GERD). Few comparative studies exist which assess the indications for and short- or long-term outcome of open Nissen fundoplication (ONF) and laparoscopic Nissen fundoplication (LNF) for pediatric GERD. We investigated the frequency of reoperation and(More)
OBJECTIVE To determine the characteristics of inflammatory bowel disease (IBD) in young patients. STUDY DESIGN Uniform data were collected from a cohort of patients with IBD who were enrolled from January 2000 to November 2002 at six pediatric centers (Pediatric IBD Consortium). RESULTS Of 1370 children in the registry, the mean age at IBD diagnosis was(More)
OBJECTIVES Rural Alaska Natives have a high prevalence of iron deficiency and Helicobacter pylori infection. The objective of this study was to estimate the prevalence of iron deficiency, iron-deficiency anemia, and active H pylori infection among school-aged children in rural Alaska. METHODS We enrolled 68% (688) of the 7- to 11-year-old children from 10(More)
Commercial serologic assays accurately detect adult Helicobacter pylori infection. Their use in children remains controversial. An ELISA to detect H. pylori IgG in children was developed and compared with three commercial assays. ELISA standardization was done with sera from all ages and validation was done with another cohort of sera with known H. pylori(More)