Benjamin Cassell

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BACKGROUND Tricyclic antidepressants (TCAs) have efficacy in treating irritable bowel syndrome (IBS). Some clinicians use TCAs to treat residual symptoms in inflammatory bowel disease (IBD) patients already on decisive IBD therapy or with quiescent inflammation, although this strategy has not been formally studied. GOALS The aim of this study was to(More)
BACKGROUND The beta-2 adrenergic receptor (ADRB2) is an important target for epinephrine, a neurotransmitter in pain signalling. ADRB2 haplotypes affect receptor expression and ligand response, and have been linked to painful non-GI disorders. AIMS To assess whether ADRB2 polymorphisms (rs1042713, rs1042714) are risk alleles for functional GI (FGID) and(More)
Most cloud providers improve resource utilization by having multiple tenants share the same resources. However, this comes at the cost of reduced isolation between tenants, which can lead to inconsistent and unpredictable performance. This performance variability is a significant impediment for tenants running services with strict latency deadlines.(More)
Past work has shown that disk prefetching can be an effective technique for improving the performance of disk bound workloads. However, the performance gains are highly dependent on selecting a prefetch size that is appropriate for a specific system and workload. Using a prefetch size that is too small can lead to poor overall disk throughput, whereas(More)
In this paper, we introduce Mayflower, a new distributed filesystem that is co-designed from the ground up to work together with a network control plane. In addition to the standard distributed filesystem components, Mayflower has a flow monitor and manager running alongside a software-defined networking controller. This tight coupling with the network(More)
BACKGROUND The Chicago Classification (CC) uses high-resolution manometry (HRM) software tools to designate esophageal motor diagnoses. We evaluated changes in diagnostic designations between two CC versions, and determined motor patterns not identified by either version. METHODS In this observational cohort study of consecutive patients undergoing(More)
BACKGROUND Sleep disturbances are common, and perhaps are even more prevalent in irritable bowel syndrome (IBS). AIMS To determine the effect of measured sleep on IBS symptoms the following day, IBS-specific quality of life (IBS-QOL) and non-GI pain symptoms. METHODS IBS patients' sleep patterns were compared to healthy individuals via wrist-mounted(More)
BACKGROUND Irritable bowel syndrome (IBS) is a common abdominal pain disorder without an organic explanation. Abuse histories (physical, sexual, emotional) are prevalent in IBS. While abuse relates to mood disorders (depression and anxiety) also common in IBS, the influence of abuse on gastrointestinal (GI) symptoms and health-related quality of life(More)
OBJECTIVES Pharmacotherapy is a mainstay in functional gastrointestinal (GI) disorder (FGID) management, but little is known about patient attitudes toward medication regimens. Understanding patient concerns and adherence to pharmacotherapy is particularly important for off-label medication use (e.g., antidepressants) in FGID. METHODS Consecutive tertiary(More)