Benjamin Cassell

Learn More
The increasing use of key-value storage systems in performance-critical data centre applications has motivated new storage system designs that use Remote Direct Memory Access (RDMA) to reduce communication overhead. However, existing approaches that achieve low latency and high throughput do so by dedicating entire cores to RDMA message handling, including(More)
BACKGROUND Functional gastrointestinal disorders (FGID) patients report poor health-related quality of life (HRQOL) and experience high rates of psychiatric and extraintestinal functional disorder (EIFD) comorbidity. The independent influence of these comorbidities on HRQOL and symptom burden remains unknown. We sought to determine whether FGID with mood or(More)
BACKGROUND Tricyclic antidepressants (TCAs) have efficacy in treating irritable bowel syndrome (IBS). Some clinicians use TCAs to treat residual symptoms in inflammatory bowel disease (IBD) patients already on decisive IBD therapy or with quiescent inflammation, although this strategy has not been formally studied. GOALS The aim of this study was to(More)
Most cloud providers improve resource utilization by having multiple tenants share the same resources. However, this comes at the cost of reduced isolation between tenants, which can lead to inconsistent and unpredictable performance. This performance variability is a significant impediment for tenants running services with strict latency deadlines.(More)
BACKGROUND The beta-2 adrenergic receptor (ADRB2) is an important target for epinephrine, a neurotransmitter in pain signalling. ADRB2 haplotypes affect receptor expression and ligand response, and have been linked to painful non-GI disorders. AIMS To assess whether ADRB2 polymorphisms (rs1042713, rs1042714) are risk alleles for functional GI (FGID) and(More)
BACKGROUND Irritable bowel syndrome (IBS) is a common abdominal pain disorder without an organic explanation. Abuse histories (physical, sexual, emotional) are prevalent in IBS. While abuse relates to mood disorders (depression and anxiety) also common in IBS, the influence of abuse on gastrointestinal (GI) symptoms and health-related quality of life(More)
Past work has shown that disk prefetching can be an effective technique for improving the performance of disk bound workloads. However, the performance gains are highly dependent on selecting a prefetch size that is appropriate for a specific system and workload. Using a prefetch size that is too small can lead to poor overall disk throughput, whereas(More)
Over the course of the last decade, implantation of left ventricular assist devices (LVADs) has become an increasingly popular treatment strategy for patients with advanced heart failure, both as a bridge to heart transplantation and as a ‘‘destination’’ therapy. The first generation of LVADs, based on a pulsatile mechanism, was plagued by poor reliability(More)
In this paper, we introduce Mayflower, a new distributed filesystem that is co-designed from the ground up to work together with a network control plane. In addition to the standard distributed filesystem components, Mayflower has a flow monitor and manager running alongside a software-defined networking controller. This tight coupling with the network(More)
OBJECTIVES Pharmacotherapy is a mainstay in functional gastrointestinal (GI) disorder (FGID) management, but little is known about patient attitudes toward medication regimens. Understanding patient concerns and adherence to pharmacotherapy is particularly important for off-label medication use (e.g., antidepressants) in FGID. METHODS Consecutive tertiary(More)