Benjamin C. Appleton

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OBJECTIVE To determine the genetic etiology of the severe early infantile onset syndrome of malignant migrating partial seizures of infancy (MPSI). METHODS Fifteen unrelated children with MPSI were screened for mutations in genes associated with infantile epileptic encephalopathies: SCN1A, CDKL5, STXBP1, PCDH19, and POLG. Microarray studies were performed(More)
It has been postulated that the neuropeptide, oxytocin, is involved in human–dog bonding. This may explain why dogs, compared to wolves, are such good performers on object choice tasks, which test their ability to attend to, and use, human social cues in order to find hidden food treats. The objective of this study was to investigate the effect of(More)
In this paper, we examine the problem of fitting a circle to a set of noisy measurements of points from the circle's circumference, assuming independent, identically distributed GAUSSIAN measurement errors. We propose an algorithm based on Branch and Bound to obtain the Maximum Likelihood Estimate and show that this algorithm obtains the optimal estimate.(More)
Albino rabbits were exposed to repeated microwave irradiations once daily for a month. Clinical examination was carried out for a period up to one year. No changes occurred below 300 mW./cm.2. At and above this level posterior subcapsular iridescence and posterior cortical cataracts were produced. The histologic findings in posterior subcapsular iridescence(More)
Erratum to: Anim Cogn (2015) 18:767–775 DOI 10.1007/s10071-015-0843-7. Unfortunately, in the original publication the word ‘receptor’ under the sub-heading ‘The effect of gender on the efficacy of oxytocin’ has been incorrectly published as ‘peptide’. The correct text should read as below. Oestrogen is known to enhance the production of oxytocin and its(More)
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