Benjamin Brennan

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Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil

Claire L Donald, Benjamin Brennan, +22 authors Alain Kohl
PLoS neglected tropical diseases
2016

BACKGROUND The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. Little… (More)

Creation of a recombinant Rift Valley fever virus with a two-segmented genome.

Benjamin Brennan, Stephen R Welch, Angela McLees, Richard M. Elliott
Journal of virology
2011

Rift Valley fever virus (RVFV; family Bunyaviridae) is a clinically important, mosquito-borne pathogen of both livestock and humans, which is found mainly in sub-Saharan Africa and the Arabian… (More)

Emerging phleboviruses☆

Richard M. Elliott, Benjamin Brennan
Current opinion in virology
2014

The Bunyavidae family is the largest grouping of RNA viruses and arguably the most diverse. Bunyaviruses have a truly global distribution and can infect vertebrates, invertebrates and plants. The… (More)

Reverse genetics system for severe fever with thrombocytopenia syndrome virus.

Benjamin Brennan, Ping Li, +4 authors Richard M. Elliott
Journal of virology
2015

UNLABELLED Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen that was first reported in China in 2009. Phylogenetic analysis of the viral genome showed that… (More)

Generation and characterization of a recombinant Rift Valley fever virus expressing a V 5 epitope-tagged RNA-dependent RNA polymerase

Benjamin Brennan, Ping Li, Richard M. Elliott
2011

The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses… (More)

RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems

Isabelle Dietrich, Stephanie Jansen, +16 authors Stefanie Christine Becker
mSphere
2017

The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important… (More)

The Consequences of Reconfiguring the Ambisense S Genome Segment of Rift Valley Fever Virus on Viral Replication in Mammalian and Mosquito Cells and for Genome Packaging

Benjamin Brennan, Stephen R Welch, Richard M. Elliott
PLoS pathogens
2014

Rift Valley fever virus (RVFV, family Bunyaviridae) is a mosquito-borne pathogen of both livestock and humans, found primarily in Sub-Saharan Africa and the Arabian Peninsula. The viral genome… (More)

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.

Steinar Halldorsson, Anna-Janina Behrens, +5 authors Thomas A Bowden
Proceedings of the National Academy of Sciences…
2016

An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical cases and associated fatalities in China, Japan, and South Korea.… (More)

Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase.

Xiaohong Shi, Catherine H. Botting, +5 authors Richard M. Elliott
Proceedings of the National Academy of Sciences…
2016

The M genome segment of Bunyamwera virus (BUNV)-the prototype of both the Bunyaviridae family and the Orthobunyavirus genus-encodes the glycoprotein precursor (GPC) that is proteolytically cleaved to… (More)

Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids

Timothy J. Mottram, Ping Li, +4 authors Alain Kohl
PLoS neglected tropical diseases
2017

Rift Valley fever phlebovirus (RVFV; Phenuiviridae, Phlebovirus) is an important mosquito-borne pathogen of both humans and ruminants. The RVFV genome is composed of tripartite, single stranded,… (More)

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