Benjamin Brennan

Publications26
h-index11
Citations485
Highly Influential Citations30
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Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil
Background The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. Little… Expand
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Emerging phleboviruses☆
Highlights • New phleboviruses (family Bunyaviridae) have emerged in China and the US.• Tick borne phleboviruses do not encode an NSm protein.• Tick borne phleboviruses show differential… Expand
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Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins
Since 2011, there has been a large expansion in the number of emerging tick-borne viruses that have been assigned to the Phlebovirus genus. Heartland virus (HRTV) and SFTS virus (SFTSV) were found to… Expand
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Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion
Significance Severe fever with thrombocytopenia syndrome virus (SFTSV) is a deadly tick-borne viral pathogen. Since first being reported in China in 2009, SFTSV has spread throughout South Korea and… Expand
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RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems
Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV… Expand
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Creation of a Recombinant Rift Valley Fever Virus with a Two-Segmented Genome †
ABSTRACT Rift Valley fever virus (RVFV; family Bunyaviridae) is a clinically important, mosquito-borne pathogen of both livestock and humans, which is found mainly in sub-Saharan Africa and the… Expand
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Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The… Expand
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The Consequences of Reconfiguring the Ambisense S Genome Segment of Rift Valley Fever Virus on Viral Replication in Mammalian and Mosquito Cells and for Genome Packaging
Rift Valley fever virus (RVFV, family Bunyaviridae) is a mosquito-borne pathogen of both livestock and humans, found primarily in Sub-Saharan Africa and the Arabian Peninsula. The viral genome… Expand
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A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus
The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary target of the neutralizing antibody response. To better understand… Expand
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Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments
Rift Valley fever phlebovirus (RVFV) is a clinically and economically important pathogen increasingly likely to cause widespread epidemics. RVFV virulence depends on the interferon antagonist… Expand
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