Benjamin Bouvier

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Considering the important role of the cervical joint position sense on control of human posture and locomotion, accurate and reliable evaluation of neck proprioceptive abilities appears of great importance. Although the cervicocephalic relocation test (CRT) to the neutral head position (NHP) usually is used for both research and clinical purposes, its(More)
The SRY gene on the Y chromosome is a necessary and sufficient condition for the development of the male phenotype and is involved in sex-reversal pathologies. The associated SRY protein also represents a convenient model system for the study of indirect protein-DNA recognition mechanisms, in which the local plasticity of DNA may play a more important role(More)
The accurate description and analysis of protein-protein interfaces remains a challenging task. Traditional definitions, based on atomic contacts or changes in solvent accessibility, tend to over- or underpredict the interface itself and cannot discriminate active from less relevant parts. We here extend a fast, parameter-free and purely geometric(More)
BACKGROUND AND AIMS Although the role of afferent input from cervical muscles on the control of posture and locomotion is recognised, it is surprising that there is an absence of data reporting whether joint position sense at the cervical level is impaired in older healthy adults. The present experiment was designed to address this issue. METHODS Eighteen(More)
STUDY DESIGN Before and after intervention trials. OBJECTIVE To evaluate the effects of visual input and tactile stimulation of the neck on postural control during unperturbed stance and cervical joint position sense. SUMMARY OF BACKGROUND DATA Although beneficial effects on lower-limb joints proprioception have been reported when vision was available(More)
The accurate description of protein-protein interfaces remains a challenging task. Traditional criteria, based on atomic contacts or changes in solvent accessibility, tend to over or underpredict the interface itself and cannot discriminate active from less relevant parts. A recent molecular dynamics simulation study by Mihalek and co-authors concluded that(More)
Atomic-scale molecular dynamics and free energy calculations in explicit aqueous solvent are used to study the complex mechanism by which a molecule can intercalate between successive base pairs of the DNA double helix. We have analyzed the intercalation pathway for the anticancer drug daunomycin using two different methods: metadynamics and umbrella(More)
We use a physics-based approach termed ADAPT to analyse the sequence-specific interactions of three proteins which bind to DNA on the side of the minor groove. The analysis is able to estimate the binding energy for all potential sequences, overcoming the combinatorial problem via a divide-and-conquer approach which breaks the protein-DNA interface down(More)
Highly specific transcriptional regulation depends on the cooperative association of transcription factors into enhanceosomes. Usually, their DNA-binding cooperativity originates from either direct interactions or DNA-mediated allostery. Here, we performed unbiased molecular simulations followed by simulations of protein-DNA unbinding and free energy(More)