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A polyspecific, intrathecal humoral immune response against the neurotropic viruses, measles, rubella and varicella zoster virus, called “MRZ reaction” (MRZR), is present in the majority of patients with multiple sclerosis (MS). Neurosarcoidosis (NS) and acute disseminated encephalomyelitis (ADEM) are important clinical differential diagnoses of MS.(More)
OBJECTIVES Paraneoplastic neurological syndromes (PNSs) are rare disorders in association with cancer and sub-divided into "classical" and "non-classical" syndromes according to a 2004 consensus paper proposed by a panel of PNS experts. "Classical" PNSs are regarded to account for the vast majority of cases. However, systematic reports on clinical PNS(More)
OBJECTIVES Fingolimod is a well-established, highly effective immunomodulatory treatment for patients with relapsing-remitting multiple sclerosis (RRMS). However, little is known about disease course after its discontinuation. METHODS This is a case series on four patients with RRMS who had a severe reactivation after fingolimod discontinuation. RESULTS(More)
Currently used hepatocyte cell systems for in vitro assessment of drug metabolism include hepatoma cell lines and primary human hepatocyte (PHH) cultures. We investigated the suitability of the validated in vivo Basel phenotyping cocktail (caffeine [CYP1A2], efavirenz [CYP2B6], losartan [CYP2C9], omeprazole [CYP2C19], metoprolol [CYP2D6], midazolam(More)
1. Electrically evoked release of [3H]-noradrenaline ([3H]-NA) or [3H]-5-hydroxytryptamine ([3H]-5-HT) in slices of human and the rat neocortex was used to characterize presynaptic opioid receptors. 2. Release of [3H]-NA in rat neocortical slices was reduced only by the mu-receptor agonist DAMGO (pIC50: 7.27, CI95: [7.22, 7.32]; Imax: 77.6+/-1.6%;(More)
Augmenting probabilities to conditional logic yields an expressive mechanism for representing uncertainty. The principle of optimum entropy allows one to reason in probabilistic logic in an information-theoretic optimal way by completing the given information as unbiasedly as possible. In this paper, we introduce the MECoRe system that realises the core(More)
PURPOSE Because of the immune-suppressive effect of cerebral damage, stroke patients are at high risk for infections. These might result in sepsis, which is the major contributor to intensive care unit (ICU) mortality. Although there are numerous studies on infections in stroke patients, the role of sepsis as a poststroke complication is unknown. METHODS(More)
Keywords: Spectral geometry processing Vector bundles Computational topology Laplace operator Finite elements a b s t r a c t Computing the spectral decomposition of the Laplace–Beltrami operator on a manifold M has proven useful for applications such as shape retrieval and geometry processing. The standard operator acts on scalar functions which can be(More)
In the present work, we extend the theoretical and numerical discussion of the well-known Laplace–Beltrami operator by equipping the underlying manifolds with additional structure provided by vector bundles. Focusing on the particular class of flat complex line bundles, we examine a whole family of Laplacians including the Laplace–Beltrami operator as a(More)
BACKGROUND AND PURPOSE Patients with severe acute stroke are at high risk for systemic infections which are associated with an increase in morbidity and mortality; nevertheless current guidelines do not recommend prophylactic antibiotic therapy. Sensitive detection of pathogens in the blood is desirable to guide early antibiotic therapy. We studied the(More)