Benjamin A. Winston

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The unfolded protein response (UPR) is an endoplasmic reticulum (ER)-based cytoprotective mechanism acting to prevent pathologies accompanying protein aggregation. It is frequently active in tumors, but relatively unstudied in gliomas. We hypothesized that UPR stress effects on glioma cells might protect tumors from additional exogenous stress (ie,(More)
BACKGROUND The object of this work was to describe resistance to flow within a vein in a closed compartment. METHODS A vein is mathematically modeled as a collapsible cylinder with fixed perimeter exposed to extraluminal hydrostatic pressure within a closed compartment of the body. The principle of minimization of energy is used to determine the(More)
With newer-generation ceramic components used in total hip arthroplasty, component fracture is a rare complication. However rare, when ceramic component fracture does occur, prompt identification and revision is necessary as delay can lead to dramatic failure with resultant metallosis as the extremely hard ceramic debris abrades remaining components. We(More)
The long head of the biceps tendon plays an important role in shoulder stability and its functional absence has been shown to contribute to glenohumeral instability. Congenital absence of the long head to the biceps tendon is rare, although described in the literature. We report the case of an 18-year-old recreational athlete with recurrent shoulder(More)
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