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BACKGROUND The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation. METHODS We performed D-dimer testing 1 month after the discontinuation of anticoagulation in patients with a first unprovoked(More)
We assessed the predictive value of D-dimer (D-d) and residual venous obstruction (RVO), alone or in combination, for recurrent venous thromboembolism (VTE) over a 2-year follow-up in a cohort of 88 cancer patients after oral anticoagulant therapy (OAT) withdrawal following a first episode of proximal deep vein thrombosis of the lower limbs. RVO, determined(More)
OBJECTIVE To determine the effect of sex on the risk of recurrent venous thromboembolism in all patients and in patients with venous thromboembolism that was unprovoked or provoked (by non-hormonal factors). Data source Comprehensive search of electronic databases (Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials) until July 2010,(More)
Warfarin dosing is affected by clinical and genetic variants, but the contribution of the genotype associated with warfarin resistance in pharmacogenetic algorithms has not been well assessed yet. We developed a new dosing algorithm including polymorphisms associated both with warfarin sensitivity and resistance in the Italian population, and its(More)
BACKGROUND We have shown that normal D-dimer levels obtained after the discontinuation of oral anticoagulant treatment (OAT) has a high negative predictive value for recurrent venous thromboembolism (VTE). The aim of the present study was to assess the predictive value of D-dimer for recurrent VTE in subjects with a previous unprovoked event who are either(More)
The optimal duration of anticoagulation in patients with venous thromboembolism (VTE) is uncertain. We investigated whether persistently negative D-dimers in patients with vein recanalization or stable thrombotic burden can identify subjects at low recurrence risk. Outpatients with a first VTE (unprovoked or associated with weak risk factors) were eligible(More)
Common inherited thrombophilic defects such as factor V Leiden and G20120A mutation of the pro-thrombin gene interact synergistically with oral contraceptives to increase the risk of venous throm-boembolism. 1 2 The best approach to identify women at higher risk of venous thromboembolism before taking oral contraceptives is controversial. Universal(More)
Although below-knee compression elastic stockings (CES) are effective for the prevention of the postthrombotic syndrome (PTS), a substantial number of patients with deep venous thrombosis still develop PTS. In the present open-label, randomized clinical trial, we compared thigh-length with below-knee CES for the prevention of PTS. A total of 267 patients(More)
Dear Sirs, Skov et al. object that the effect of the variant allele rs7294 which is associated with higher warfarin requirements is not relevant in our dosing algorithm, its effect being significant at the univariate but not at the multivariate analysis. Skov et al. also show that there is not a complete linkage disequilibrium but a significant correlation(More)
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