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  • Daniel B. Zoccal, Annabel E. Simms, +4 authors Benedito H Machado
  • Medicine
  • The Journal of physiology
  • 2008 (First Publication: 1 July 2008)
  • Chronic intermittent hypoxia (CIH) in rats produces changes in the central regulation of cardiovascular and respiratory systems by unknown mechanisms. We hypothesized that CIH (6% O(2) for 40 s,Continue Reading
  • Benedito H Machado, Leni G. H. Bonagamba, Siok L. Dun, Ernest H. Kwok, Nae J. Dun
  • Medicine, Biology
  • Regulatory Peptides
  • 2002 (First Publication: 1 March 2002)
  • Orexin A (or hypocretin 1)-immunoreactive neurons in the rat lateral hypothalamus project to several areas of the medulla oblongata that are closely associated with cardiovascular regulation. TheContinue Reading
  • Davi J A Moraes, Mirela B Dias, Roberta Cavalcanti-Kwiatkoski, Benedito H Machado, Daniel B. Zoccal
  • Medicine, Psychology
  • Journal of neurophysiology
  • 2012 (First Publication: 1 August 2012)
  • Central mechanisms of coupling between respiratory and sympathetic systems are essential for the entrainment between the enhanced respiratory drive and sympathoexcitation in response to hypoxia.Continue Reading
  • Daniel B. Zoccal, Leni G. H. Bonagamba, Fabíola Raquel Tenório Oliveira, José Antunes-Rodrigues, Benedito H Machado
  • Medicine, Biology
  • Experimental physiology
  • 2007 (First Publication: 1 March 2008)
  • Long-term exposure to intermittent hypoxia may lead to important cardiovascular dysfunctions, such as hypertension. Rodent models of chronic intermittent hypoxia (CIH) have been used to study theContinue Reading
  • Davi J A Moraes, Melina P da Silva, +5 authors Benedito H Machado
  • Medicine, Biology
  • The Journal of Neuroscience
  • 2013 (First Publication: 4 December 2013)
  • The respiratory pattern generator modulates the sympathetic outflow, the strength of which is enhanced by challenges produced by hypoxia. This coupling is due to the respiratory-modulatedContinue Reading
  • Yaroslav I. Molkov, Daniel B. Zoccal, Davi J. A. Moraes, Julian F R Paton, Benedito H Machado, Ilya A. Rybak
  • Psychology, Medicine
  • Journal of neurophysiology
  • 2011 (First Publication: 1 June 2011)
  • Hypertension elicited by chronic intermittent hypoxia (CIH) is associated with elevated activity of the thoracic sympathetic nerve (tSN) that exhibits an enhanced respiratory modulation reflecting aContinue Reading
  • C. Sevoz, Anne Nosjean, João Carlos Callera, Benedito H Machado, Michel Hamon, Raul F. Laguzzi
  • Biology, Medicine
  • The American journal of physiology
  • 1996 (First Publication: 1 July 1996)
  • Intra-atrial administration of phenylbiguanide has been shown to trigger, through the stimulation of vagal afferent C-fibers, reflex bradycardia, hypotension, and sympathoinhibition classically knownContinue Reading
  • Valdir de Andrade Braga, Renato N Soriano, +4 authors Benedito H Machado
  • Medicine, Chemistry
  • The Journal of physiology
  • 2007 (First Publication: 15 June 2007)
  • Peripheral chemoreflex activation with potassium cyanide (KCN) in awake rats or in the working heart-brainstem preparation (WHBP) produces: (a) a sympathoexcitatory/pressor response; (b) bradycardia;Continue Reading
  • Renata C. H. Barros, Leni G. H. Bonagamba, Roberta Okamoto-Canesin, Mauro de Oliveira, Benedito H Machado
  • Medicine
  • Autonomic Neuroscience
  • 2002 (First Publication: 1 May 2002)
  • Although intravenous (iv) injection of potassium cyanide (KCN) activates the arterial chemoreflex, it has been questioned whether cytotoxic hypoxia reproduces a physiological stimulus such as hypoxicContinue Reading