Learn More
The dynamic reshaping of tissues during morphogenesis results from a combination of individual cell behaviors and collective cell rearrangements. However, a comprehensive framework to unambiguously measure and link cell behavior to tissue morphogenesis is lacking. Here we introduce such a kinematic framework, bridging cell and tissue behaviors at an(More)
Drosophila germ-band extension (GBE) is an example of the convergence and extension movements that elongate and narrow embryonic tissues. To understand the collective cell behaviours underlying tissue morphogenesis, we have continuously quantified cell intercalation and cell shape change during GBE. We show that the fast, early phase of GBE depends on cell(More)
impact efforts in tissue engineering of skeletal tissues. Eye movements in vertebrates are controlled by six extraocu-lar muscles innervated by three of the cranial nerves – the ocu-lomotor, trochlear and abducens. Incorrect development of this wiring network can lead to eye movement disorders, such as the congenital condition Duane retraction syndrome(More)
impact efforts in tissue engineering of skeletal tissues. Eye movements in vertebrates are controlled by six extraocu-lar muscles innervated by three of the cranial nerves – the ocu-lomotor, trochlear and abducens. Incorrect development of this wiring network can lead to eye movement disorders, such as the congenital condition Duane retraction syndrome(More)
by ecdysteroids and prevented by the morphostatic juvenile hormone (JH). The fruitfly Drosophila enabled discovery of the genetics of steroid regulation, but due to the evolutionary reduction of dependence on JH in the fly, the molecular mode of JH action remains unclear. We used RNAi in insects with a strict ancestral JH control of metamorphosis to define(More)
  • 1