Benedetto Pini

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We used optimized immunohistochemistry (IHC) with the D5F3 antibody for detection of tumours in a prospective study of 307 pulmonary adenocarcinomas. Cases positive by IHC (1+, 2+, 3+) were further investigated by fluorescent in situ hybridization (FISH). Of 307 cases, 22 (7.2%) were moderately intensely positive (2+/3+); 18 of these (82%) were also(More)
Melanocytic differentiation has been described in rare cases of melanin-containing neuroendocrine tumours of the lung [1–5], thyroid [6] and thymus [7]. In some of the cases, neuroendocrine granules and melanosomes were lying free in the cytoplasm of tumour cells, thus indicating true coexpression of melanocytic and neuroendocrine differentiation. On the(More)
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