Benedetta Frida Baldi

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A computational application to predict, probe and interpret the activities of a series of congeneric compounds inhibiting extracellular signal-regulated kinase 2 protein kinase is presented. The study shows that molecular dynamics coupled with molecular mechanics Poisson-Boltzmann solvent accessible surface area free energy estimation is a suitable tool for(More)
Genomics and Epigenetics Division, Garvan Institute of Medical Research, NSW 2010, Australia St Vincent’s Clinical School, University of New South Wales, NSW 2052, Australia Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, VIC 3052, Australia Department of Medical Biology, University of Melbourne, VIC 3010, Australia(More)
Well-designed videogames provide intuitive and engaging ways of understanding and interacting with highly complex systems. The aim of this study was to explore the use of videogames as a lens for the design of bioinformatics visualisation tools, with a particular focus on molecular graphics systems designed to explore 3D structures of proteins. We conducted(More)
We sought to explore how knowledge of videogames could inform the design of complex digital interfaces for bioinformatics visualization tools. Aquaria is an open-source web resource for visual exploration of protein structures. We present the results of a series of workshops conducted with participants who have expertise in videogame design and development.(More)
Schizophrenia is a multifactorial complex disease with a large impact on society. Many hypotheses have been proposed over the years to explain its causes, and genomics and functional genomic approaches may shed light on the reason behind these controversies and discrepancies. We give an overview of several approaches that have been used to identify the(More)
Long Term Potentiation (LTP) is thought to be one of the main molecular mechanisms underlying the processes of memory and learning in the brain. One of the most studied mechanisms is the synaptic potentiation mediated by glutamate and its receptors resulting in conductance changes of the post-synaptic membrane. Brain-derived neurotrophic factor and its(More)
Modelling at the Mesoscale: a Novel Approach to Protein-Protein Interaction and Multicomplex Formation. Baldi Bendetta Frida The Post-Synaptic Density (PSD) is a proteinaceous organelle present on the membrane of excitatory spines that is at the core of signal processing in neuronal transmission. The major components of the PSD have been identified as well(More)
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