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BACKGROUND Combined cardiac operation and carotid endarterectomy using our technique is an acceptable approach to simultaneous correction of both carotid and cardiac disease. METHODS From August 1989 to March 1998, 121 consecutive patients underwent combined operations. Of these patients, 112 had coronary artery bypass grafting and carotid endarterectomy,(More)
The enhancement of host susceptibility to endotoxin (lipopolysaccharide, LPS) by toxic shock syndrome toxin-1 (TSST-1) is an important mechanism in the pathogenesis of toxic shock syndrome. In these studies, we sought to determine whether an endotoxin-neutralizing monoclonal antibody could be useful in the treatment of toxic shock syndrome. We isolated a(More)
We present a methodology for promoting situational awareness of an enterprise network using only network artifacts discernible from network protocol logs. We utilized latent Dirichlet allocation (LDA) over two corpora, the first composed of search queries and the second composed of external domain names issued by enterprise users through the network proxy(More)
We present the GOSMR architecture, a modular agent architecture designed to actuate web browsers and other network applications, and demonstrate the importance of modeling how users think about the past and future in accurately modeling network traffic. The architecture separates the hierarchical generation of goals and incentives (Behaviors) from(More)
Both monoclonal antibody (MAb) and polyclonal antibody (PAb) directed against the shared core/lipid A region of lipopolysaccharide (LPS) (endotoxin) provide protection during experimental gram-negative bacterial sepsis. Although these preparations have not been compared, clinical trials administering either preparation to septic patients have been(More)
Enterprise computer networks are filled with users performing a variety of tasks, ranging from business-critical tasks to personal interest browsing. Due to this multi-modal distribution of behaviors, it is non-trivial to automatically discern which behaviors are business-relevant and which are not. Additionally, it is difficult to infer communities of(More)
We present a method for detecting when a user's remote access account has been compromised in such a way that an attacker model can be learned during operations. A Naive Bayes model is built for each user that stores the likelihood for each remote session based on a variety of features available in the access logs. During operation, we leverage Expectation(More)
Monoclonal antibodies (MAbs) directed against gram-negative bacterial lipopolysaccharide (endotoxin, LPS) are currently being evaluated as an adjunctive form of therapy for lethal gram-negative bacterial sepsis and shock. The exact binding site within the LPS molecule against which antibody should be directed in order to maximize both cross-reactivity among(More)
Moving target (MT) technologies seek to protect cyber systems by making them less homogenous, less static, and less deterministic in order to increase the complexity required for a successful cy-ber attack. While such technologies provide a promising avenue for defense, they are often associated with significant performance costs. Therefore, it is necessary(More)