Ben Nguyen

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Severe chronic peripheral arterial disease (PAD) manifests as critical limb ischemia (CLI) with a 5-year mortality rate >70%. Mesenchymal stem cells (MSC) show promise to minimize CLI progression and restore perfu-sion in experimental models, but approaches suffer from minimal homing to ischemic tissue and require clinically impractical direct injections of(More)
Homing of iv-infused stem cells to diseased tissues may be critical for cell therapies and is frequently an obstacle to successful cell therapy. We have previously shown that molecular responses from the mechanotransduction effects of pulsed focused ultrasound (pFUS) in normal murine skeletal muscle generate a " molecular zip-code " consisting of local(More)
Maximal homing of iv-infused MSC may be critical for cell therapies. Molecular responses from the primarily mechanical effects of pulsed focused ultrasound (pFUS) (i.e., mechanotransduction) in healthy or diseased murine kidneys generate a " molecular zip-code " consisting of local increases in chemoattractants (cytokines, chemo-kines, cell adhesion(More)
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