Ben C. Creelan

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10538 Background: Indoleamine 2,3-dioxygenase (IDO) has recently been proposed as an inducible promoter of tumor-related immunosuppression through the metabolism of tryptophan into kynurenine. Our(More)
We created a vaccine in which irradiated allogeneic lung adenocarcinoma cells are combined with a bystander K562 cell line transfected with hCD40L and hGM-CSF. By recruiting and activating dendritic(More)
BACKGROUND Omaveloxolone is a semisynthetic oleanane triterpenoid that potently activates Nrf2 with subsequent antioxidant function. We conducted a first-in-human Phase I clinical trial (NCT02029729)(More)