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Diffusion within the extracellular and perivascular spaces of the brain plays an important role in biological processes, therapeutic delivery, and clearance mechanisms within the central nervous system. Recently, ultrasound has been used to enhance the dispersion of locally administered molecules and particles within the brain, but ultrasound-mediated(More)
Severe chronic peripheral arterial disease (PAD) manifests as critical limb ischemia (CLI) with a 5-year mortality rate >70%. Mesenchymal stem cells (MSC) show promise to minimize CLI progression and restore perfu-sion in experimental models, but approaches suffer from minimal homing to ischemic tissue and require clinically impractical direct injections of(More)
Homing of iv-infused stem cells to diseased tissues may be critical for cell therapies and is frequently an obstacle to successful cell therapy. We have previously shown that molecular responses from the mechanotransduction effects of pulsed focused ultrasound (pFUS) in normal murine skeletal muscle generate a " molecular zip-code " consisting of local(More)
Maximal homing of iv-infused MSC may be critical for cell therapies. Molecular responses from the primarily mechanical effects of pulsed focused ultrasound (pFUS) (i.e., mechanotransduction) in healthy or diseased murine kidneys generate a " molecular zip-code " consisting of local increases in chemoattractants (cytokines, chemo-kines, cell adhesion(More)
Objectives Thalamotomy of the ventral intermediate nucleus (VIM) is effective in alleviating medication resistant tremor in patients with essential tremor (ET) and Parkinson's disease (PD). MRI guided Focused Ultra-sound (MRgFUS) is an innovative technology that enables non-invasive thalamotomy via thermal ablation. Methods Thirty eight ET and PD patients(More)
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