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Current perspective on the pathogenesis of Graves' disease and ophthalmopathy.

• Bellur S Prabhakar, Rebecca S. Bahn, Terry J. Smith
• Endocrine reviews
• 2003

Graves' disease (GD) is a very common autoimmune disorder of the thyroid in which stimulatory antibodies bind to the thyrotropin receptor and activate glandular function, resulting in… (More)

miR-30 Regulates Mitochondrial Fission through Targeting p53 and the Dynamin-Related Protein-1 Pathway

• Jincheng Li, Stefan Donath, Yanrui Li, Danian Qin, Bellur S Prabhakar, Peifeng Li
• PLoS genetics
• 2010

miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation… (More)

Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells…

• Chenthamarakshan Vasu, R E Dogan, Mark J. Holterman, Bellur S Prabhakar
• Journal of immunology
• 2003

Fms-like tyrosine kinase receptor 3-ligand (Flt3-L) and GM-CSF cause expansion of different subsets of dendritic cells and skew the immune response toward predominantly Th1 and Th2 type,… (More)

A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs.

• Yu-ichi Goto, Michelle G de Silva, Antonio Toscani, Bellur S Prabhakar, Abner Louis Notkins, M. S. Lan
• The Journal of biological chemistry
• 1992

A subtraction library was constructed from human insulinoma (beta cell tumor) and glucagonoma (alpha cell tumor) cDNA phagemid libraries. Differential screening of 153 clones with end-labeled mRNAs… (More)

Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation.

• Nicolás Pérez, Subha Karumuthil-Melethil, Ruobing Li, Bellur S Prabhakar, Mark J. Holterman, Chenthamarakshan Vasu
• Journal of immunology
• 2008

Costimulatory ligands CD80 and CD86 have different binding preferences and affinities to their receptors, CD28 and CTLA-4. Earlier, we demonstrated that CD80 binds to CTLA-4 with higher affinity and… (More)

P2Z-Independent and P2Z receptor-mediated macrophage killing by Pseudomonas aeruginosa isolated from cystic fibrosis patients.

• O Zaborina, N. Misra, +5 authors Ananda M. Chakrabarty
• Infection and immunity
• 1999

We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aeruginosa isolated from the lungs of a cystic fibrosis (CF) patient secretes multiple enzymes with nucleoside diphosphate… (More)

Trichloroethene-induced autoimmune response in female MRL +/+ mice.

• Mahjabeen Khan, Bhupendra S. Kaphalia, Bellur S Prabhakar, Mary F. Kanz, G. A. Shakeel Ansari
• Toxicology and applied pharmacology
• 1995

Trichloroethene (TCE) has been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) and scleroderma in humans. However, experimental studies have not been… (More)

GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms.

• Palash Bhattacharya, Anupama Gopisetty, Balaji B. Ganesh, Jian Rong Sheng, Bellur S Prabhakar
• Journal of leukocyte biology
• 2011

In our earlier work, we had shown that GM-CSF treatment of CBA/J mice can suppress ongoing thyroiditis by inducing tolerogenic CD8α(-) DCs, which helped expand and/or induce CD4(+)Foxp3(+) Tregs. To… (More)

Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity.

• Balaji B. Ganesh, Palash Bhattacharya, Anupama Gopisetty, Bellur S Prabhakar
• Journal of interferon & cytokine research : the…
• 2011

Autoimmune thyroid diseases (AITD) are one of the most common organ-specific autoimmune disorders, of which Hashimoto's thyroiditis (HT) and Graves' disease (GD) are 2 of the most common clinical… (More)

Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.

• Adeeb M Al-Zoubi, Elena V. Efimova, +4 authors Bellur S Prabhakar
• The Journal of biological chemistry
• 2001

We identified a novel cDNA (IG20) that is homologous to cDNAs encoding a protein differentially expressed in normal and neoplastic cells (DENN-SV) and human MADD (MAPK-activating death… (More)

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