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Functions, therapeutic applications, and synthesis of retinoids and carotenoids.
Carotenoids Rosana Álvarez,† Beleń Vaz,† Hinrich Gronemeyer,‡ and Ángel R. de Lera*,† †Departamento de Química Orgańica, Centro de Investigacioń Biomed́ica (CINBIO), and Instituto de InvestigaciońExpand
9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice
The retinoid X receptors (RXRs) are ligand-activated transcription factors which heterodimerize with a number of nuclear hormone receptors, thereby controlling a variety of (patho)-physiologicalExpand
Pyrene-Containing ortho-Oligo(phenylene)ethynylene Foldamer as a Ratiometric Probe Based on Circularly Polarized Luminescence
In this manuscript, we report the first synthesis of an organic monomolecular emitter, which behaves as a circularly polarized luminescence (CPL)-based ratiometric probe. The enantiopure helicalExpand
Hollow-shelled nanoreactors endowed with high catalytic activity.
Hollow-shelled nanoreactors have emerged as efficient structures to maximize the potential of nanoparticles in the field of catalysis. In this Concept article, we underline the importance of both theExpand
Macroscale Plasmonic Substrates for Highly Sensitive Surface-Enhanced Raman Scattering**
The fabrication of macroscale optical materials from plasmonic nanoscale building blocks is the focus of much current multidisciplinary research. In these macromaterials, the nanoscale properties areExpand
Nanoreactors for simultaneous remote thermal activation and optical monitoring of chemical reactions.
We report herein the design of plasmonic hollow nanoreactors capable of concentrating light at the nanometer scale for the simultaneous performance and optical monitoring of thermally activatedExpand
Total synthesis of peridinin and related C37-norcarotenoid butenolides.
As an extension of our synthesis of symmetrical carotenoids, the preparation of the highly functionalized C37-norcarotenoid butenolide peridinin (1), its 6'-epi- and 11'Z stereoisomers has beenExpand
The Stille reaction in the synthesis of carotenoid butenolides: synthesis of 6'-epi-peridinin.
A new strategy for carotenoid butenolides has been developed that is based in part in halogen-selective Stille cross-coupling of dihalogenated ylidenebutenolide segment 2 and highly functionalizedExpand
Stable helical peptoids via covalent side chain to side chain cyclization.
Peptoids are oligomeric N-substituted glycines with potential as biologically relevant compounds. Helical peptoids provide an attractive fold for the generation of protein-protein interactionExpand
Synthesis of symmetrical carotenoids by a two-fold Stille reaction.
beta-Carotene 1 and (3R,3'R)-zeaxanthin 2 have been stereoselectively prepared in a highly convergent fashion by a 2-fold Stille cross-coupling reaction. The C(12)-pentaenylbis-stannane 8 is theExpand