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Particle deposition in the small bronchial tubes (generations six through twelve) is strongly influenced by the vortex-dominated secondary flows that are induced by axial curvature of the tubes. In this paper, we employ particle destination maps in conjunction with two-dimensional, finite-time Lyapunov exponent maps to illustrate how the trajectories of(More)
The laminar flow in the small bronchial tubes is quite complex because of the presence of vortex-dominated, secondary flows. Factors contributing to this complexity are the unsteady nature of the inhale-exhale breathing cycle and the geometrical characteristics of the bronchial tubes. To investigate unsteady effects on flows and particle transport, unsteady(More)
The DigitalLung project represents an attempt to develop a multi-scale capability for simulating human respiration with application to predicting the effects of inhaled particulate matter. To accomplish this objective, DigitalLung integrates macroscale models of integrative human physiology, meso-to-microscale computational fluid dynamics simulations of a(More)
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