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BACKGROUND Previous studies have shown protective effects of brain natriuretic peptide (BNP) against the postmyocardial infarction (MI) remodelling process. The transcription factor NF-κB is known to play an important role after MI. AIMS To investigate if NF-κB is involved in the protective effects of BNP against adverse post-MI remodelling. METHODS(More)
BACKGROUND Microvascular reflow is crucial for myocyte survival during ischaemia/reperfusion injury. AIMS We aimed to assess if salvianolate, a highly purified aqueous extract from Radix salviae miltiorrhizae, could improve impaired microvascular reflow induced by ischaemia/reperfusion injury, using a porcine closed-chest model. METHODS Left anterior(More)
BACKGROUND The purpose of this study was to assess whether the dynamic changes in coronary flow velocity and coronary flow velocity reserve (CFVR) by intracardiac echocardiography (ICE) within proximal coronary arteries are related to myocardial perfusion status and infarct size in a myocardial ischemia-reperfusion injury model. METHODS In 14 dogs, left(More)
BACKGROUND Endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) have different biological properties, but their potential for synergy in the treatment of injured myocardium has not been studied extensively. AIM To determine if outcome could be improved by simultaneously transplanting MSCs and EPCs into a rat model of isoproterenol(More)
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