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  • Carlos López-Gómez, Almudena Pino-Ángeles, +11 authors Laura Alvarado Leyva
  • Biology, Medicine
  • PloS one
  • 2013 (First Publication: 29 April 2013)
  • TRAIL and TRAIL Receptor genes have been implicated in Multiple Sclerosis pathology as well as in the response to IFN beta therapy. The objective of our study was to evaluate the association of theseContinue Reading
  • Concepción Núñez, María Carmen Cénit, +9 authors Elena Urcelay
  • Biology, Medicine
  • Journal of medical genetics
  • 2014 (First Publication: 1 June 2014)
  • BACKGROUND Recombinant interferon β (IFNβ) is a first-line therapy for relapsing-remitting multiple sclerosis (MS), with a proven effect on the inflammatory activity. Neutralising antibodies againstContinue Reading
  • María Jesús Pinto-Medel, Juan Antonio García-León, Begoña Oliver-Martos, Carlos Zabala López-Gómez, Laura Leyva
  • Biology, Medicine
  • Journal of Neuroimmunology
  • 2012 (First Publication: 1 February 2012)
  • Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expressionContinue Reading
  • Isaac Hurtado-Guerrero, María Jesús Pinto-Medel, +6 authors Begoña Oliver-Martos
  • Medicine
  • PloS one
  • 2017 (First Publication: 19 January 2017)
  • Interferon beta (IFNß) is a common treatment used for multiple sclerosis (MS) which acts through the activation of the JAK-STAT pathway. However, this therapy is not always effective and currentlyContinue Reading
  • Carlos López-Gómez, Begoña Oliver-Martos, +5 authors Laura Alvarado Leyva
  • Medicine
  • Journal of neurology, neurosurgery, and…
  • 2015 (First Publication: 3 March 2015)
  • OBJECTIVE We aimed to assess the effects of interferon β (IFNβ) treatment on the expression of the splice variants of the Tumour necrosis factor-Related Apoptosis Inducing Ligand (TRAIL) and itsContinue Reading