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T cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK) lymphocytes constitute an essential component of the innate immune system in tumor surveillance, reproduction, and defense against microbes and viruses. Here, we show that the transcription factor Bcl11b was expressed in all T cell compartments and was indispensable(More)
Helicobacter pylori infection affects human populations of all ages. This gastric bacterium exists in spiral form and the reported viable but nonculturable coccoid form. The present study aims to examine the probable role of the coccoid form in H. pylori infection by comparing the seroprevalences of the spiral and the coccoid forms in children with(More)
INTRODUCTION This study aimed to refine the current quantitative fluorescent polymerase chain reaction (QF-PCR) screen to detect X chromosome anomalies for prenatal diagnosis in the major Southeast-Asian populations. METHODS 100 amniotic fluid samples from Chinese, Malay and Indian origins were subjected to QF-PCR using the X chromosome markers, HPRT, X22(More)
Though peritonitis is a common complication in Continuous Ambulatory Peritoneal Dialysis (CAPD), tuberculous peritonitis has been reported in only twelve CAPD patients in the world English literature to date. Successful outcome in those reported cases involved antituberculous therapy and in the majority, catheter removal and conversion to maintenance(More)
INTRODUCTION This is a retrospective study to assess the accuracy of the Alvarado score in predicting appendicitis for patients with right iliac fossa pain. MATERIALS AND METHODS This is a retrospective study of consecutive patients with suspected appendicitis. The Alvarado score was computed from the admission notes and correlated with the final outcome(More)
The emergence of antibiotic-resistant Helicobacter pylori is of concern in the treatment of H. pylori-associated gastroduodenal diseases. As the organism was reported to bind gastric mucin, we used porcine gastric mucin as substrate to assess the antiadhesive property of polysaccharides derived from Spirulina (PS), a commercially available microalga,(More)
TPS224 Background: Relapsed/refractory PTCL and NKL after conventional chemotherapy carry an extremely poor prognosis and there is currently no proven treatment available. Panobinostat (PAN), a pan-deacetylase inhibitor targets epigenetic and multiple oncogenic pathways, while bortezomib (BTZ) exerts pleotropic antitumor effects, including the inhibition of(More)
Despite the success of BCR-ABL1 tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML), resistance to tyrosine kinase inhibitors remains a therapeutic challenge. One strategy used to overcome resistance is combination of existing BCR-ABL1 tyrosine kinase inhibitors with agents that target alternative pathways. We report that inhibition(More)