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A new cyclooxygenase-2 inhibitor (code: PCX-3) was synthesized as a sodium salt form of celecoxib, a non-steroidal anti-inflammatory drug (NSAID), and tested for its anticancer activity using human colon adenocarcinoma cells (HT-29) in vitro. Anti-proliferative effect of HT-29 cells by PCX-3 in DPPC/Chol liposomes was more effective than the free PCX-3 by(More)
OBJECTIVE OBJECTIVE It is now established that "dippers" whose blood pressure (BP) falls at night have lower cardiovascular risks than nondippers without nocturnal BP fall. Our previous study on the middle-aged general population in Korea indicated increased 24-hour urinary (24U) sodium excretion was associated with increased nighttime BPs. Therefore, we(More)
OBJECTIVE Detection of individual difference in salt-induced blood pressure (BP) elevation is important to know who should reduce salt intake for preventing hypertension, but the diagnosis of salt sensitivity requires a time-consuming protocol for testing BP changes in response to salt loading and depletion. Since WHO-CARDIAC Study indicated BP was higher(More)
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