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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
New therapeutic strategies are needed to combat the tuberculosis pandemic and the spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease, which remain a seriousExpand
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Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis
The small-molecule indolcarboxamide is a potential drug candidate for treating multidrug-resistant tuberculosis. Combating the Scourge of TB Tuberculosis (TB) caused by the bacterium MycobacteriumExpand
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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Candidate antibacterials are usually identified on the basis of their in vitro activity. However, the apparent inhibitory activity of new leads can be misleading because most culture media do notExpand
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Direct inhibitors of InhA are active against Mycobacterium tuberculosis
4-Hydroxy-2-pyridones, direct inhibitors of the mycobacterial protein InhA, are active against multidrug-resistant Mycobacterium tuberculosis. “Rediscovering” InhA for Treating TB Isoniazid, a keyExpand
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A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis
Growing evidence suggests that the presence of a subpopulation of hypoxic non-replicating, phenotypically drug-tolerant mycobacteria is responsible for the prolonged duration of tuberculosisExpand
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UDP-galactose and Acetyl-CoA transporters as Plasmodium multidrug resistance genes
A molecular understanding of drug resistance mechanisms enables surveillance of the effectiveness of new antimicrobial therapies during development and deployment in the field. We used conventionalExpand
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Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.
Tetrahydropyrazolo[1,5-a]pyrimidine scaffold was identified as a hit series from a Mycobacterium tuberculosis (Mtb) whole cell high through-put screening (HTS) campaign. A series of derivatives ofExpand
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Risk of Hepatitis B Virus (HBV) Reactivation and Role of Anti-Viral Prophylaxis in Lymphoma Patients with Past HBV Infection (HBV Antigen negative but anti-Hepatitis B core antibody positive)
Hepatitis B virus (HBV) infection, defined by the presence of HBV surface antigen (HBsAg), increases the risk of HBV reactivation and current guidelines recommend that patients who are HBV-infectedExpand
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Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages
The ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and the development of vaccines and drugs. Thus, the elaboration of a protocol for the in vitroExpand
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Corrrection to Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Novel Antitubercular Agents.
We recognize the contribution of Associate Prof. Dr. Thomas Dick to the research described in the manuscript (ACS Med. Chem. Lett.2013, 4 (5), pp 451–455) and therefore include him as an author. HeExpand
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