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A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant.
TLDR
The data show that Lys289 critically influences the catalytic pathway of pol β, and some of these analogues improve the fidelity of K289M. Expand
Total syntheses of isonaamine C and isonaamidine E.
The total syntheses of two alkaloids isolated from a marine sponge of the Leucetta sp. have been accomplished in 6 and 7 steps starting from a 4,5-diiodoimidazole derivative. Grignard mediatedExpand
Total synthesis and cytotoxicity of Leucetta alkaloids.
TLDR
The total synthesis of a number of representative natural products isolated from Leucetta and Clathrina sponges containing a polysubstituted 2-aminoimidazole are described, and for comparative purposes a series of naphthimodazole-containing family members are included. Expand