Beatriz G-T. Pogo

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The presence of viral nucleic acid sequences and antigens from a variety of conventional viruses in selected brain regions of cases of Alzheimer's disease (AD), diagnosed pathologically, was investigated using molecular hybridization and immunocytochemical techniques. Seven DNA and 4 RNA viruses were used as probes in 18 AD and 5 control brains. With(More)
A conditional lethal, temperature-sensitive mutant of vaccinia, defective in assembly of the virus envelope and maturation, was characterized and shown to mimic exactly the aberrations produced by rifampicin. Analyses of the infection at restrictive and permissive temperatures were conducted with electron microscopy, isotopic pulse-chase experiments in(More)
Recent studies of histone metabolism in the cells of higher organisms have indicated that the basic proteins of the nucleus are modified after synthesis by the attachment of acetyl,'-7 methyJ,8-'2 and, possibly, phosphoryl groups.'3 16 The biological significance of these structural modifications of proteins associated with DNA in the chromatin'7 remains an(More)
Acetylation of histones takes place along the salivary gland chromosomes of Chironomus thummi when RNA synthesis is active. It can be observed but not measured quantitatively by autoradiography of chromosome squashes. The "fixatives" commonly used in preparing squashes of insect chromosomes preferentially extract the highly acetylated "arginine-rich"(More)
Inhibition of nuclear DNA polymerase activity in cells infected with vaccinia virus parallels the development of a nuclease activity similar to one associated with the virus particles. Both phenomena occur in the absence of protein synthesis, implying that incoming particles are responsible for the effects observed. Experimental evidence is presented(More)