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1 We thank the audience of the Health Economics Seminar at the Universidad Carlos III for useful comments. All redundancies are due to the second author. All missing explanations are due to the third one. Otherwise, the usual disclaimer applies. 2 BBVA. Abstract It is commonly argued that in recent years pharmaceutical companies have directed their R&D(More)
Ischemic heart disease (IHD), more common among transplant recipients than in the general population, accounts for approximately 50% of cardiovascular deaths. Despite its importance, only a few publications have addressed the prevalence of and risk factors for this complication. This was a retrospective cohort study in 2382 cadaver renal transplant(More)
The reductive aminase from Aspergillus oryzae (AspRedAm) was combined with a single alcohol dehydrogenase (either metagenomic ADH-150, an ADH from Sphingobium yanoikuyae (SyADH), or a variant of the ADH from Thermoanaerobacter ethanolicus (TeSADH W110A)) in a redox-neutral cascade for the biocatalytic alkylation of amines using primary and secondary(More)
[reaction: see text] The regioselective functionalization of 4,12-dibromoparacyclophane via electrophilic aromatic substitution is reported for the first time. The functionalization of the paracyclophane backbone allows the development of a new family of paracyclophane-based phosphines (named ParaPhos) that opens the possibility of improved catalyst(More)
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