Beatriz Campo Fernandez

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Ribosomes are molecular machines that function in polyribosome complexes to translate genetic information, guide the synthesis of polypeptides, and modulate the folding of nascent proteins. Here, we report a surprising function for polyribosomes as a result of a systematic examination of the assembly of a large ribonucleoprotein complex, the vault particle.(More)
BACKGROUND Autologous hematopoietic stem cell transplantation (HSCT) of gene-modified cells is an alternative to enzyme replacement therapy (ERT) and allogeneic HSCT that has shown clinical benefit for adenosine deaminase-deficient (ADA-deficient) SCID when combined with reduced intensity conditioning (RIC) and ERT cessation. Clinical safety and therapeutic(More)
  • P B Timpson, Mrs W S Farlsh, +53 authors Samuel Hibben
  • 2012
Never before has Houston witnessed such a basketball game as that staged at the City Auditorium last Monday evening. It was the fastest, hardest fought, and consequently, the most interesting game ever played in Houston. An unusually large crowd saw the game, unusually large, because not only basketball fans were attracted to see the game, but also many(More)
BACKGROUND AIMS Gene therapy by autologous hematopoietic stem cell transplantation (HSCT) represents a new approach to treat sickle cell disease (SCD). Optimization of the manufacture, characterization and testing of the transduced hematopoietic stem cell final cell product (FCP), as well as an in depth in vivo toxicology study, are critical for advancing(More)
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