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PURPOSE 5-Fluorouracil-based chemoradiotherapy before total mesorectal excision is currently the standard treatment of Stage II and III rectal cancer patients. We used known predictive pharmacogenetic biomarkers to identify the responders to preoperative chemoradiotherapy in our series. METHODS AND MATERIALS A total of 93 Stage II-III rectal cancer(More)
e14065 Background: We are trying to identify factors that predict which patients are likely to high risk of toxicity by analyzing candidate genes in the irinotecan pathways in order to identify useful tools to improve mCRC patient management. METHODS Genomic DNA was genotyped for UGT1A1 (*28,*60 and *93) from all 101 patients, irinotecan was administered(More)
AIM Polymorphisms in the metabolism, detoxification or DNA repair pathways have been proposed as potential predictors of response to 5-fluorouracil and oxaliplatin. We have studied the predictive value of a set of germline genetic polymorphisms in metastatic colorectal cancer patients treated with mFolfox-6. MATERIALS & METHODS A total of 72 patients,(More)
Natural language requirements documents are often verified by means of some reading technique. Some recommendations for defining a good reading technique point out that a concrete technique must not only be suitable for specific classes of defects, but also for a concrete notation in which requirements are written. Following this suggestion, we have(More)
In this article, an empirical evaluation and review of some metrics–based verification heuristics for use cases are presented. This evaluation is based on empirical data collected from requirements documents developed by Software Engineering students at the University of Seville using REM, a free XML–based requirements management tool developed by one of(More)
In this article, we present an approach for the automatic verification of software requirements documents. This approach is based on the representation of software requirements in XML and the usage of the XSLT language not only to automatically generate requirements documents, but also to verify some desired quality properties and to compute some metrics.(More)
BACKGROUND The objectives of this pilot study were to evaluate the safety and efficacy of the central nervous system stimulant methylphenidate in the management of asthenia in breast cancer patients treated with docetaxel. PATIENTS AND METHODS Patients with early breast cancer who presented asthenia >3 on the Visual Analogue Scale (VAS) after the first(More)
<b>Context</b>. Many reports support the fact that some psycho--social aspects of software engineers are key factors for the quality of the software development process and its resulting products. Based on the experience of some of the authors after more than a year of practising <i>mindfulness</i>---a meditation technique aimed to increase clearness of(More)