Beatriz Abril

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OBJECTIVE To estimate the frequency, mechanisms and predictive factors of sleep apnoea syndrome (SAS) in a large group of children and adults with type I (CMI) and II (CMII) Chiari malformation (CM). BACKGROUND The anatomical and functional integrity of both respiratory circuits and lower cranial nerves controlling the upper airway is necessary for(More)
STUDY OBJECTIVES To investigate the occurrence of restless legs syndrome (RLS) in narcolepsy with cataplexy (NC). DESIGN A case-control study assessing the frequency of comorbidity of RLS and NC in three European sleep disorder centers. PATIENTS Three sleep research centers recruited 184 NC patients and 235 age-matched controls. INTERVENTIONS N/A. (More)
OBJECTIVES To investigate decision-making and addictive behaviors in narcolepsy-cataplexy (NC). NC is caused by the loss of hypothalamic neurons that produce hypocretins. The hypocretin system plays a crucial role in sleep, wakefulness, and energy homeostasis, and is also involved in emotion regulation, reward processing, and addiction. SETTING Academic(More)
Gamma-hydroxybutyrate (GHB) has re-emerged as a major treatment for narcolepsy. As dopaminergic transmission is clearly involved in the pathophysiology of restless legs syndrome (RLS), and GHB reduces dopamine release, one may hypothesize that RLS may occur in narcolepsy in the presence of GHB. We report a case of narcolepsy with a severe occurrence of(More)
INTRODUCTION Analysis of nocturnal sleep in infantile autism has been presented in various studies. However, there has been no systematization including the different structural and paroxystic alterations at the same time as permitting the development of a general theory of the effect of sleep on prognosis and treatment, particularly in a spectrum in which(More)
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