Beatrix I. Sneller

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The main goal of this work is the generation of ground-truth data for the validation of atrophy measurement techniques, commonly used in the study of neurodegenerative diseases such as dementia. Several techniques have been used to measure atrophy in cross-sectional and longitudinal studies, but it is extremely difficult to compare their performance since(More)
Automatic algorithms in conjunction with longitudinal MR brain images can be used to measure cerebral atrophy, which is particularly pronounced in several types of dementia. An atrophy simulation technique has been devised to facilitate validation of these algorithms. To make this model of atrophy more realistic we simulate acquisition artefacts which are(More)
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