Beatrice P Spector

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108 cases of cancer in patients with A-T, an autosomal-recessive disorder of neurologic, endocrine, and immunologic dysfunction were collected by the ICR worldwide. 71/108 cases (66%) developed lymphoid malignancies at a median age of 8 yrs. (range 2-45 yrs.) with a male/female ratio=1.6. When U.S. cases were compared to an age/sex matched sample from the(More)
A-T is an autosomal-recessive syndrome characterized by neurologic abnormalities, variable ID, and a 10% prevalence rate of cancer at a mean age of 12.5 yrs. A-T patients have excess proportions of lymphoid tumors and selected carcinomas compared to types in the general population. A-T lymphomas resemble nonlymph-oblastic childhood forms and differ from the(More)
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