Beatrice Heagan

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Electron microscopic studies of the sickling phenomenon have described at least three different structural arrangements of sickled hemoglobin, including empty hexagonal crystals, microtubules, and solid rods. It is unlikely that sickling results in several different polymers, and it is essential to determine the true structure of sickled hemoglobin in order(More)
Increased viscosity, fragility and distortion of erythrocytes from patients with inherited defects of hemoglobin (Hb) have been related to sol-gel and solcrystal transformation. A method has been developed in this labortory which permits definition of the nature of molecular assembly underlying abnormal hemoglobin interactions. Cell free solutions of HbAA,(More)
The specific defect in molecules of sickle hemoglobin (HbS) has been known for many years (1), but the nature of the assembled polymers of HbS which distort susceptible erythrocytes remains unclear. Several structural forms of sickled hemoglobin have been observed in electron microscopic studies, including a mat-like arrangement of fibers (2), empty(More)
The discoid shape of human blood platelets is supported by a circumferential microtubule (MT) organized in many loops or coils. A recent study reported from the authors' laboratory demonstrated that significant numbers of MT rings could be isolated from resting platelets by simultaneous exposure to detergent and a small amount of fixative. This method has(More)