Beatrice Benkert

Learn More
In Pseudomonas aeruginosa, the narK(1)K(2)GHJI operon encodes two nitrate/nitrite transporters and the dissimilatory nitrate reductase. The narK(1) promoter is anaerobically induced in the presence of nitrate by the dual activity of the oxygen regulator Anr and the N-oxide regulator Dnr in cooperation with the nitrate-responsive two-component regulatory(More)
To provide an integrated bioinformatics platform for a systems biology approach to the biology of pseudomonads in infection and biotechnology the database SYSTOMONAS (SYSTems biology of pseudOMONAS) was established. Besides our own experimental metabolome, proteome and transcriptome data, various additional predictions of cellular processes, such as(More)
Denitrification and arginine fermentation are major parts of the anaerobic metabolism of Pseudomonas aeruginosa, which is important for biofilm formation and infection. The two-component regulatory system NarX-NarL is part of the underlying network and is required for denitrifying growth. All target promoters identified so far are activated by NarL. In this(More)
Modern high-throughput techniques allow for the identification and quantification of hundreds of metabolites ofa biological system which cover central parts of the metabolome. Due to the amount and complexity of obtained data there is an increasing need for the development of appropriate computational interpretation methods. A novel data analysis pipeline(More)
High throughput technologies like transcriptomics using DNA arrays or metabolomics employing a combination of gas chromatography with mass spectrometry provide valuable information about cellular processes. However, the measurements are often highly corrupted with noise of the experimental data which makes it sometimes difficult to draw reliable(More)
Metabolomics emerges as one key aspect of systems biology , since quantifying the dynamic set of metabolites reveals the effect of altered gene expression and protein pattern and thus complements transcriptomics and pro-teomics. By high-throughput techniques, such as measuring metabolites by gas chromatography-mass spectrometry (GC-MS), enormous data(More)
  • 1