Beate Weidenthaler

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Filaggrin, a basic protein of the stratum corneum, was named as such because of its capability to aggregate keratin intermediate filaments in vitro. To investigate its filament-aggregating capability in vivo, we performed immunoelectron microscopy in three autosomal dominant genodermatoses serving as in vivo models of abnormalities of keratin filament(More)
Recent biochemical and morphological investigations have provided evidence for a heterogeneous composition of keratohyalin in human skin. A major component is filaggrin. In interfollicular epidermis the heterogeneity of keratohyalin is not directly visible, whereas in normal ridged skin bicomponent keratohyalin is revealed by electron microscopy. Skin(More)
We report on a 61-year-old patient with sclerodermiform skin lesions of the extremities and polyneuropathy. Borrelia (B.) burgdorferi DNA was detected in lesional skin by the polymerase chain reaction. Serological testing revealed IgG antibodies to B. burgdorferi. Histology revealed an inflammatory stage of a sclerotic reaction in the lesional skin. The(More)
Wir berichten über einen 61jährigen Patienten mit akralen sklerodermiformen Hautveränderungen und sensibler Polyneuropathie, bei dem in einem Biopsat aus einem erkrankten Hautareal am Oberschenkel Borrelien-DNS mit der Polymerase-Kettenreaktion nachgewiesen werden konnte. Serologisch waren spezifische Antikörper der Klasse IgG gegen Borrelia (B.)(More)
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