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Auditory Brain stem Responses (ABR) were performed prospectively in 24 severely constitutionally dyslexic children. None of the subjects showed any signs of organic or psychologic abnormality. The results were matched with a corresponding group of normal children. The response latencies of the two groups were almost identical (no statistically significant(More)
PURPOSE Neonatal seizures are common, especially in prematurity. Phenobarbital (PB) currently represents the antiepileptic drug (AED) of choice, despite being related to increased neuronal apoptosis in animal models and cognitive impairment in human subjects. Levetiracetam (LEV) may have a more favorable profile since it does not cause neuronal apoptosis in(More)
BACKGROUND Empagliflozin is a potent, selective sodium glucose cotransporter 2 (SGLT2) inhibitor in development as an oral antidiabetic treatment. This QT interval study assessed potential effects of empagliflozin on ventricular repolarisation and other electrocardiogram (ECG) parameters. METHODS A randomised, placebo-controlled, single-dose,(More)
BACKGROUND Tiotropium is generally well tolerated; however, there has been debate whether antimuscarinics, particularly tiotropium administered via Respimat(®) Soft Mist(™) Inhaler, may induce cardiac arrhythmias in a vulnerable subpopulation with cardiovascular comorbidity. The aim of this study was to provide evidence of the cardiac safety of tiotropium(More)
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