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SUMMARY BACKGROUND It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults>15 years after a simple FS. METHODS Eight healthy subjects (5 men) with a history of simple FS (FS+ group)(More)
OBJECTIVES In the current classification of epilepsies two forms of temporal lobe epilepsy (TLE) were included: mesial and lateral (neocortical) TLE. We aimed at identifying prognostic factors for the surgical outcome of lesional neocortical TLE. METHODS We included consecutive patients who had undergone presurgical evaluation including ictal video-EEG(More)
PURPOSE   Secondarily generalized tonic-clonic seizure (SGTCS) may occur rarely in temporal lobe epilepsy (TLE), but SGTCS is the major risk factor for sudden death and for seizure-related fatal injuries. Our aim was to investigate clinical factors associated with the occurrence of SGTCS in TLE by addressing two questions: (1) What clinical features(More)
BACKGROUND The pathophysiology of cervical dystonia is poorly understood. Increased brain iron deposition has been described in different movement disorders. Our aim was to investigate brain iron content in patients with cervical dystonia, using R2* relaxation rate, a validated MRI marker of brain iron level. METHODS Twelve female patients with primary(More)
PURPOSE Can a complementary 3-D T1-weighted sequence (MPRAGE) facilitate the evaluation of contrast enhancement in patients with widespread and early contrast enhancement in our standard 3-D T1-weighted FLASH sequence? MATERIAL AND METHODS Twenty patients with 27 breast lesions were examined with both FLASH and MPRAGE sequences. The MR examinations were(More)
In mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), structural abnormalities are present not only in the hippocampus but also in the white matter with ipsilateral predominance. Although the timing of epilepsy onset is commonly associated with clinical and semiological dissimilarities, limited data exist regarding white matter diffusion(More)
The importance of the sleep related breathing disorders (obstructive sleep apnea syndrome, central sleep apnea, and Cheyne-Stokes breathing) in the pathophysiology crebro- and cardiovascular disorders is well known. The relationship of sleep related breathing abnormalities and epilepsy is also important but underestimated in the daily practice. The relation(More)
Mortality in epilepsy is 2-3 times higher than in the age- and sex-matched general population. It is the highest in young male epilepsy patients with generalised tonic-clonic seizures living in low socio-economical situation. The main factors of early mortality unrelated to seizures are the neurological conditions underlying epilepsy. Suicide is an(More)
1. Is there an association between febrile seizure and hippocampal damage independent of epilepsy? Can simple febrile seizure causes hippocampal abnormalities? Are there any hippocampal abnormalities in healthy patients 15-20 years after a simple febrile seizure ........ 12 2. What clinical/neuroimaging features can be differentiated between TLE patients(More)
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