Bbrge S Nielsen

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The pharmacology of (2S,4R)-4-methylglutamic acid, (2S,4S)-4-methylglutamic acid and (S)- and (R)-4-methyleneglutamic acids (obtained in high chemical and enantiomeric purity from racemic 4-methyleneglutamic acid by chiral HPLC using a Crownpak CR(+) column), was examined in binding experiments using rat brain ionotropic glutamate receptors, and in(More)
Homomeric and heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunits GluR1o and GluR3o were expressed in Spodoptera frugiperda (Sf9) insect cells. Membranes containing the recombinant receptors showed a doublet of bands of the expected size (99-109 kDa) after western immunoblotting which was shifted to a single band upon(More)
Received (received date) Revised (revised date) The large TPC (95 m 3) of the ALICE detector at the CERN LHC was commissioned in summer 2006. The first tracks were observed both from the cosmic ray muons and from the laser rays injected into the TPC. In this article the basic principles of operating the 266 nm lasers are presented, showing the installation(More)
Received XXX A Large Ion Collider Experiment (ALICE) is the only experiment at the Large Hadron Collider (LHC) dedicated to the study of heavy ion collisions. The Time Projection Chamber (TPC) is the main tracking detector covering the pseudo rapidity range |η| < 0.9. It is designed for a maximum multiplicity dN/dy= 8000. The aim of the laser system is to(More)
Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift to the right of the dose-response curve(More)
The first measurements of xF-dependent single-spin asymmetries of identified charged hadrons, pi+/-, K+/-, and protons, from transversely polarized proton-proton collisions at 62.4 GeV at RHIC are presented. Large asymmetries are seen in the pion and kaon channels. The asymmetries in inclusive pi+ production, AN(pi+), increase with xF from 0 to(More)
Results on the production of identiied particles in e + e ? collisions from the DELPHI detector at LEP are reported. The production of identiied particles, , K , p= p, were measured over the full momentum range using the identiica-tion power of the Ring Imaging Cherenkov detectors. The rates were measured separately in jets originating from light or heavy(More)
(RS)-2-Amino-3-(5-tert-butyl-3-hydroxy-4-isothiazolyl)propionic acid (thio-ATPA), a 3-isothiazolol analogue of (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA), has previously been shown to be a relatively weak AMPA receptor agonist at native (S)-glutamic acid ((S)-Glu) receptors (EC(50)=14 microM), comparable in potency with ATPA(More)
In an analysis of multihadronic events recorded at LEP by DELPHI in the years 1992 through 1994, charged hadrons are identiied using the measurement of their energy loss and their Cherenkov angle. Rapidity correlations of-, proton-proton, and-proton pairs are compared. The agreement with the string and cluster fragmentation models is tested. For those pairs(More)
The (R) and (S) forms of 5-amino-2-hydroxyvaleric acid (2-OH-DAVA) and 5-amino-4-hydroxyvaleric acid (4-OH-DAVA) were designed as structural hybrids of the 4-aminobutyric acidB (GABAB) agonist (R)-(-)-4-amino-3-hydroxybutyric acid [(R)-(-)-3-OH-GABA] and the GABAB antagonist 5-aminovaleric acid (DAVA). (S)-(-)-2-OH-DAVA and (R)-(-)-4-OH-DAVA showed a(More)
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