Baudoin Delépine

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Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer's disease (AD) after APOE. We report that BIN1 transcript levels were increased in AD brains and identified a novel 3 bp insertion allele ∼28 kb upstream of BIN1, which increased (i) transcriptional activity(More)
PURPOSE To compare the thickness of the retinal nerve fiber layer (RNFL) and the macular volume and of normal and amblyopic eyes between children and adults who had strabismic or anisometropic amblyopia. PATIENTS AND METHODS Patients with unilateral amblyopia were consecutively included from June 2006 to June 2007. The macular volume and the RNFL(More)
Genetically-encoded biosensors offer a wide range of opportunities to develop advanced synthetic biology applications. Circuits with the ability of detecting and quantifying intracellular amounts of a compound of interest are central to whole-cell biosensors design for medical and environmental applications, and they also constitute essential parts for the(More)
Despite the increase in recent years in the portfolio of added-value chemicals that can be microbially produced, the design process still remains a complex system, costly and rather slow. To overcome such limitations, the development of Computer-Aided-Design (CAD) tools is necessary to design production pathway that systematically screen metabolic databases(More)
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