Bastian Jentsch

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Photodynamic therapy (PDT) uses laser light to activate a photosensitizer that has been absorbed preferentially by cancer cells after systemic administration. A phototoxic reaction ensues resulting in cell death and tissue necrosis. Some cells, however, may survive PDT. This study was performed to determine if surviving human breast cancer cells (MCF-7) can(More)
BACKGROUND Histone deacetylases (HDACs) are known to be associated with an overexpression in different types of cancer such as colon and prostate cancer. In this study we aimed to evaluate the protein expression of class I HDACs in urothelial carcinoma of the bladder. METHODS A tissue microarray containing 348 tissuesamples from 174 patients with a(More)
BACKGROUND AND OBJECTIVE Photodynamic therapy (PDT) is the combination of a photosensitizer with laser light to induce preferential destruction of malignant cells. In this study two new photosensitizers--5,10,15,20-meta-tetra(hydroxyphenyl) chlorin (m-THPC) and m-THPC MethoxyPEG2000 derivative (m-THPC MD)--were tested, both for their dark toxicity, i.e.,(More)
A nine-month-old golden retriever bitch was presented with exercise intolerance and recurrent nasal discharge. Based on clinical, radiographic and ultrasonographic examination, a diagnosis of rhinitis, situs inversus totalis and tricuspid valve insufficiency was established. The results of video- and electron microscopy studies of the respiratory epithelium(More)
An experimental model in rats was used to assess the stimulant effect of an isolated nerve segment on peripheral nerve regeneration. In a first group of animals, 14 mm of the femoral nerve was removed unilaterally and the gap was bridged with femoral vein taken from the other side. In a second group, the intervention differed in that a 2-mm nerve segment(More)
Photodynamic therapy (PDT) is a promising alternative method for clinical cancer treatment. In the present study, cells from four breast carcinomas, seven ovarian carcinomas of various stages of differentiation, and ascites from a diffuse metastatic tumor were treated by PDT in vitro. Tetra(m-hydroxyphenyl)-chlorin (m-THPC) was used as the photosensitizer.(More)
Spontaneous anastomosis of vessels approximately 100 mu in diameter was studied in experiments on rats. The vessels--both arteries and veins--were transected and the stumps joined with a suture. In the veins, a fully functional anastomosis developed within 5 to 7 days after the intervention. Spontaneous anastomosis was, however, relatively uncommon with(More)
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