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  • Csaba Szabó, Basilia Zingarelli, M. O'connor, Andrew L. Salzman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 5 March 1996)
  • The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo formation of ONOO- has been demonstrated in shock and inflammation.Expand
  • E. Amiel Gilad, Hector R. Wong, +4 authors Csaba Szabó
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1998 (First Publication: 1 June 1998)
  • The role of melatonin as an immunomodulator is well established. Recent reports showed that melatonin exerts protective effects in septic and hemorrhagic shock and in inflammation. The expression ofExpand
  • Basilia Zingarelli, Maeve Sheehan, Paul W. Hake, Michael O'Connor, Alvin Denenberg, James Cook
  • Biology, Medicine
  • The Journal of Immunology
  • 2003 (First Publication: 15 December 2003)
  • Peroxisome proliferator activator receptor-γ (PPARγ) is a nuclear receptor that controls the expression of several genes involved in metabolic homeostasis. We investigated the role of PPARγ duringExpand
  • Csaba Szabó, Basilia Zingarelli, Andrew L. Salzman
  • Biology, Medicine
  • Circulation research
  • 1996 (First Publication: 1 June 1996)
  • Stimulation of vascular smooth muscle with bacterial lipopolysaccharide (LPS) and proinflammatory cytokines induces the expression of a distinct isoform of NO synthase (inducible NOS [iNOS])Expand
  • Basilia Zingarelli, Andrew L. Salzman, Csaba Szabó
  • Medicine, Biology
  • Circulation research
  • 1998 (First Publication: 13 July 1998)
  • The nuclear enzyme poly (ADP-ribose) synthetase (PARS) has been shown to play an important role in the pathogenesis of ischemia/reperfusion injury and circulatory shock. The aim of this study was toExpand
  • Salvatore Cuzzocrea, Basilia Zingarelli, Paul W. Hake, Andrew L. Salzman, Csaba Szabó
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1998 (First Publication: 1 February 1998)
  • In vitro studies have demonstrated that mercaptoethylguanidine (MEG), a selective inhibitor of the inducible NO synthase (iNOS), is also effective as a scavenger of peroxynitrite (a potent cytotoxicExpand
    DNA single strand breakage and activation of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) contribute to peroxynitrite-induced cellular injury. We investigated the role of PARS activation inExpand