Basavaiah Umesha

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The pyrazole moiety containing analogs of podophyllotoxin as potential antimitotic agents were synthesized in five step reactions via chalcone route. The first step is the synthesis of chalcone (2a–d) by the reaction of substituted acetophenones with p-tolualdehyde in the presence of sodium hydroxide in water–ethanol mixture. The cyclopropyl ketones (3a–d)(More)
In the title compound, C17H16O3, the dihedral angle between the mean planes of the benzene rings is 57.1 (1)°. The mean plane of the ketone group is twisted by 10.0 (5)° from that of the di-meth-oxy-phenyl ring. The two di-meth-oxy-phenyl groups are twisted slighly from the mean plane of the phenyl ring, with C-O-C-C torsion angles of 6.4 (2) and -7.9 (2)°(More)
Benzo[d][1,3]dioxole gathered pyrazole derivatives (4a–i) were synthesized by the reaction of chalcones with phenyl hydrazine in presence of absolute alcohol as a solvent. Chalcones were prepared by the Claisen-Schmidt reaction between 1-(benzo[d][1,3]dioxol-5-yl)ethanone (2) and substituted aromatic aldehydes. The synthesized compounds were characterized(More)
A series of chalcones, dihydropyrimidinone and dihydropyrimidinethione derivatives were synthesized in good yields by Claisen Schmidt reaction of acetophenones with substituted aldehydes in the presence of sodium hydroxide in water-ethanol mixture followed by the condensation reaction of chalcones with urea and thiourea in ethanol respectively. The(More)
The pyrazole analogues of podophyllotoxin were synthesized by the chalcone route. This route attracts the attention because of its simple operating conditions and easy availability of the chemicals. Initially, benzylideneacetophenones (chalcones) were prepared in high yields by Claisen-Schmidt reaction of acetophenones with 4-(methylthio)benzaldehyde. The(More)
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