Basavaiah Umesha

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The pyrazole analogues of podophyllotoxin were synthesized by the chalcone route. This route attracts the attention because of its simple operating conditions and easy availability of the chemicals. Initially, benzylideneacetophenones (chalcones) were prepared in high yields by Claisen-Schmidt reaction of acetophenones with 4-(methylthio)benzaldehyde. The(More)
an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract. Podophyllotoxin belongs to the cyclolignan family of natural products. It exhibits cathartic, cytotoxic, antimitotic, anticancer and other(More)
The pyrazole moiety containing analogs of podophyllotoxin as potential antimitotic agents were synthesized in five step reactions via chalcone route. The first step is the synthesis of chalcone (2a–d) by the reaction of substituted acetophenones with p-tolualdehyde in the presence of sodium hydroxide in water–ethanol mixture. The cyclopropyl ketones (3a–d)(More)
Benzo[d][1,3]dioxole gathered pyrazole derivatives (4a–i) were synthesized by the reaction of chalcones with phenyl hydrazine in presence of absolute alcohol as a solvent. Chalcones were prepared by the Claisen-Schmidt reaction between 1-(benzo[d][1,3]dioxol-5-yl)ethanone (2) and substituted aromatic aldehydes. The synthesized compounds were characterized(More)
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