Kanchugarakoppal S. Rangappa13
Kesturu S. Girish9
Mahalingam S. Sundaram7
Kempaiah Kemparaju6
13Kanchugarakoppal S. Rangappa
9Kesturu S. Girish
7Mahalingam S. Sundaram
6Kempaiah Kemparaju
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  • Kodagahalli S. Rakesh, Swamy Jagadish, Ajjampura C. Vinayaka, Mahadevappa Hemshekhar, Manoj Paul, Ram M. Thushara +9 others
  • 2014
Thrombocytopenia is a serious issue connected with the pathogenesis of several human diseases including chronic inflammation, arthritis, Alzheimer's disease, cardiovascular diseases (CVDs) and other oxidative stress-associated pathologies. The indiscriminate use of antibiotics and other biological drugs are reported to result in thrombocytopenia, which is(More)
  • Hosadurga K. Keerthy, Manoj Garg, Chakrabhavi D. Mohan, Vikas Madan, Deepika Kanojia, Rangappa Shobith +7 others
  • 2014
The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles from alcohols, malanonitrile and phenols is reported. These novel 2-amino-chromene-3-carbonitriles showed cytotoxicity in human acute myeloid leukemia(More)
  • Manoj Paul, Mahadevappa Hemshekhar, Ram M. Thushara, Mahalingam S. Sundaram, Somanathapura K. NaveenKumar, Shivanna Naveen +11 others
  • 2015
Thrombocytopenia in methotrexate (MTX)-treated cancer and rheumatoid arthritis (RA) patients connotes the interference of MTX with platelets. Hence, it seemed appealing to appraise the effect of MTX on platelets. Thereby, the mechanism of action of MTX on platelets was dissected. MTX (10 μM) induced activation of pro-apoptotic proteins Bid, Bax and Bad(More)
BACKGROUND Dibenzoazepine (DB) derivatives are important and valuable compounds in medicinal chemistry. The synthesis and chemotherapeutic properties of naturally occurring DBs and different heterocyclic moiety tethered DBs are reported. Herein, we report the DB-fused hybrid structure that containing isoxazolines (DBIs) and their anti-cancer activity, which(More)
  • Venkatachalaiah Srinivasa, Mahalingam S. Sundaram, Sebastian Anusha, Mahadevappa Hemshekhar, Siddaiah Chandra Nayaka, Kempaiah Kemparaju +3 others
  • 2014
The classical antivenom therapy has appreciably reduced snakebite mortality rate and thus is the only savior drug available. Unfortunately, it considerably fails to shield the viper bite complications like hemorrhage, local tissue degradation and necrosis responsible for severe morbidity. Moreover, the therapy is also tagged with limitations including(More)
  • Hanumantharayappa Bharathkumar, Mahalingam S. Sundaram, Swamy Jagadish, Shardul Paricharak, Mahadevappa Hemshekhar, Daniel Mason +5 others
  • 2014
Glycoside hydrolases catalyze the selective hydrolysis of glycosidic bonds in oligosaccharides, polysaccharides, and their conjugates. β-glucosidases occur in all domains of living organisms and constitute a major group among glycoside hydrolases. On the other hand, the benzoxazinoids occur in living systems and act as stable β-glucosides, such as(More)
BACKGROUND MMP-13, a zinc dependent protease which catalyses the cleavage of type II collagen, is expressed in osteoarthritis (OA) and rheumatoid arthritis (RA) patients, but not in normal adult tissues. Therefore, the protease has been intensively studied as a target for the inhibition of progression of OA and RA. Recent reports suggest that selective(More)
Thrombocytopenia is a major hematological concern in oxidative stress-associated pathologies and chronic clinical disorders, where premature platelet destruction severely affects the normal functioning of thrombosis and hemostasis. In addition, frequent exposure of platelets to chemical entities and therapeutic drugs immensely contributes in the development(More)
Drugs such as necopidem, saripidem, alpidem, zolpidem, and olprinone contain nitrogen-containing bicyclic, condensed-imidazo[1,2-α]pyridines as bioactive scaffolds. In this work, we report a high-yield one pot synthesis of 1-(2-methyl-8-aryl-substitued-imidazo[1,2-α]pyridin-3-yl)ethan-1-onefor the first-time. Subsequently, we performed in silico(More)
Condensed-bicyclic triazolo-thiadiazoles were synthesized via an efficient "green" catalyst strategy and identified as effective inhibitors of PTP1B in vitro. The lead compound, 6-(2-benzylphenyl)-3-phenyl-[1,2,4]triazolo[3][1,3,4]thiadiazole (BPTT) was most effective against human hepatoma cells, inhibits cell invasion, and decreases neovasculature in(More)